Biological and biomedical implications of the co-evolution of pathogens and their hosts

By Mark E. J. Woolhouse, J. Webster, E. Domingo, B. Charlesworth, B. Levin. Nature Genetics, 2002

828 citations recorded by the source corpus.

Subfields: Genetics, Infectious Diseases, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/004b5e3795e26e6b9ed3c40261dc1248dacfffcb

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Citations in the corpus

Estimation of potential global pandemic influenza mortality on the basis of vital registry data from the 1918-20 pandemic: a quantitative analysis. (2006, background): “54 In addition to this uncertainty about what is genetically possible, future mortality could be larger if the 1918–20 pattern of low older adult mortality were in fact due to some acquired immunity from the pandemics of the mid-19th century.”
HOST PARASITE INTERACTIONS BETWEEN FRESHWATER PHYTOPLANKTON AND CHYTRID FUNGI (CHYTRIDIOMYCOTA) 1 (2004, background): “Coevolution is defined as the process of reciprocal adaptive genetic changes in two or more species (Woolhouse et al. 2002).”
Bacteria–phage coevolution as a driver of ecological and evolutionary processes in microbial communities (2014, background): “This mode of coevolution is often termed an ‘arms race’ due to the escalation of defense and counterdefense traits by both species (Dawkins & Krebs, 1979; Woolhouse et al., 2002; Gandon et al., 2008).”
Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved (2010, neutral): “Host-pathogen co-evolution is characterised by reciprocal adaptive changes in interacting species 11 .”
The co-evolution of host cationic antimicrobial peptides and microbial resistance (2006, background): “The key issues in microbial infection — adherence to, and invasion of, host cells, and evasion of host defences, on the one hand, and the host strategies to prevent microbial colonization and tissue damage on the other — are a result of ongoing, highly dynamic co-evolutionary processe”
Population Genomics of Parallel Adaptation in Threespine Stickleback using Sequenced RAD Tags (2010, background): “3-Mb interval in the published stickleback genome are several candidate targets of balancing selection, namely genes implicated in the first line of defense against pathogens [108]: ZEB1 (ENSGACG00000017648), and two adjacent APOL genes (ENSGACG00000017778, ENSGACG00000017779).”
An ecological and evolutionary perspective on human–microbe mutualism and disease (2007, background): “The view that highly virulent pathogens originated recently, with selection inevitably reducing virulence over time, has been supplanted by the realization that there is an optimal level of virulence (for the pathogen) that depends on the biology of its host interaction”
A new theory of MHC evolution: beyond selection on the immune genes (2009, neutral): “…‘cost of resistance’ might explain why only relatively few studies detect genotype frequency changes in response to parasite selection (Little 2002; but see Westerdahl et al. 2004), and why temporal patterns of host–parasite coevolution are difficult to demonstrate (Woolhouse et al. 2002).”
Development, specificity and sublethal effects of symbiont‐conferred resistance to parasitoids in aphids (2012, background): “Such 380 genotype × genotype interactions lead to negative frequency-dependent selection between 381 hosts and parasites and thereby promote genotypic variation (Woolhouse et al. 2002).”
Cyclical Parthenogenesis in Daphnia: Sexual Versus Asexual Reproduction (2009, background): “Several lines of evidence suggest that Daphnia-parasite coevolution follows “Red Queen” dynamics with no directional increase in fitness of both antagonists over time (Hamilton et al. 1990; Woolhouse et al. 2002; Ebert 2008).”