Inflammatory cells during wound repair: the good, the bad and the ugly.

By Paul Martin, S. Leibovich. Trends in Cell Biology, 2005

1,366 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/93e5104095364448222073e364ab6aef1759bb0f

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Citations in the corpus

Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials (2015, background): “Inflammation is triggered by cells when they undergo injury and necrosis and is a vital step in the healing process [79].”
Targeting the tumour vasculature: insights from physiological angiogenesis (2010, background): “Neutrophils and macrophages recruited to the site of injury protect the wound from invading bacteria through their phagocytic function and the secretion of toxic mediators such as proteases and reactive oxygen species (ROS”
Protective immune mechanisms in helminth infection (2007, background): “Alternatively activated macrophages might contribute to wound healing by clearing matrix and cell debris and by releasing cytokines, growth factors and angiogenic factors that promote fibroplasia and angiogenesis even at sterile site”
Microglial physiology: unique stimuli, specialized responses. (2009, background): “The role of macrophages in wound repair is well documented and part of the innate immune response (99).”
Vitamin C and Immune Function (2017, background): “Leukocytes, particularly neutrophils and monocyte-derived macrophages, are major players in wound healing [108].”
Metalloproteinases and their inhibitors: regulators of wound healing. (2008, background): “It has also been suggested that inflammatory cells are required for other aspects of wound healing (i.e., to release cytokines and growth factors that stimulate cell proliferation and migration); however, this remains to be completely elucidated (Martin & Leibovich, 2005).”
The inflammatory response to cell death. (2008, background): “There is similar evidence that wound healing is actually prolonged by neutrophilic inflammation (99).”
Differential Roles of Macrophages in Diverse Phases of Skin Repair (2010, background): “Their number increases during the phase of inflammation, peaks during the phase of tissue formation, and gradually declines during the maturation phase (9).”
Macrophages in skin injury and repair. (2011, neutral): “This multipotent protein promotes fibrosis by directly stimulating mesenchymal cells and fibroblasts (Martin and Leibovich 2005).”
Wound healing: cellular mechanisms and pathological outcomes (2020, background): “Most neutrophils are extruded from the wound site as they adhere to the fibrin scab, while others are removed by innate clearance mechanisms such as macrophage efferocytosis [17].”
Wound repair at a glance (2009, background): “Although the issue of whether inflammatory cells are an essential requirement for repair remains controversial (Martin and Leibovich, 2005), it is clear that these cell populations exert a profound influence on all other cells within the wound and in the surrounding tissue.”