Alzheimer's disease beta-amyloid peptides are released in association with exosomes.

By L. Rajendran, Masanori Honsho, T. Zahn, P. Keller, K. Geiger, P. Verkade, K. Simons. Proceedings of the National Academy of Sciences of the United States of America, 2006

1,321 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/9309b3ef45005ab19214014cbe8830b232d72af0

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Citations in the corpus

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA (2009, background): “In agreement with the possible role of the microvesicle transfer of altered mtDNA in AD, recent evidence has also pointed out the pathogenic Ab peptides can be secreted from the cells in association with exosomes and exosomal proteins have been found to accumulate in the plaques of AD patient brains”
Identification of pre-clinical Alzheimer’s disease by a profile of pathogenic proteins in neurally-derived blood exosomes: a case-control study (2014, background): “Exosomes accept amyloid precursor protein from early endosomes, after its cleavage by b-secretase, and the Ab peptide fragments subsequently generated by g-secretase are secreted in exosomes [17].”
Exosomes: secreted vesicles and intercellular communications (2011, background): “involved in the formation/transfer of pathogenic proteins (such as prions and amyloid deposits) [31,32].”
Autophagy, amyloidogenesis and Alzheimer disease (2007, positive): “A fraction of the A may be exocytosed from cells via MVBs in association with intralumenal vesicles (exosomes), remnants of which can be detected in plaques of AD patient brains (Rajendran et al., 2006).”
Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses (2011, background): “Exosomes are secreted by neural, epithelial, muscle and stem cells, and their range of proposed functions include contribution to tissue repair (exosomes secreted by mesenchymal stem cells modify host cardiac tissue) (89), communication within the nervous system (exosomes are secreted by neurons, Sc”
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication (2013, background): “Several pathogenic proteins involved in CNS diseases, such as prions [18], b-amyloid peptide [77], superoxide-dismutase [78], and asynuclein [79] are released from cells in association with exosomes.”
Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. (2015, background): “In the central nervous system, proteins such as amyloid-β peptide may be transferred via exosomes and thus exacerbate and extend neuronal injury (63, 64).”
Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival (2010, background): “…that exosome-mediated export could play a critical role in the processing of proteins associated with neurodegenerative diseases, because -amyloid (A ) peptides and prions were found to be externalized from cells via this pathway (Fevrier et al., 2004; Rajendran et al., 2006; Vella et al., 2008).”
Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “Because exosomal proteins accumulate in plaques of patient brains, exosomes are thought to play a role in the pathogenesis of Alzheimer’s disease (Rajendran et al., 2006).”
Exosomal cell-to-cell transmission of alpha synuclein oligomers (2012, background): “In fact, only a small fraction of Abeta peptide is found associated with exosomes [80], which supports our observations.”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Exosomes containing amyloid peptides tau-ph sphorylated at Thr-181 are potential biomarkers for Alzheimer’s diseas [202,203].”
Pathogenic Protein Seeding in Alzheimer’s Disease and Other Neurodegenerative Disorders (2011, background): “Like other pathogenic proteins, A β can be taken up, modified and secreted by cells in vitro 92, 93 , and it also is present in the CSF 94 .”
The biology, function, and biomedical applications of exosomes (2020, neutral): “This process involves the deregulation of ECE1/2 (endothelin-converting enzyme 1/2), effectively resulting in an increase in oligomerized A b in exosomes from the brains of APP-transgenic mice ( 135 ).”