Astrocytes and Glioblastoma cells release exosomes carrying mtDNA
By Michele Guescini, Susanna Genedani, Vilberto Stocchi, Luigi Francesco Agnati. Journal of neural transmission, 2009
631 citations recorded by the source corpus.
Cells can exchange information not only by means of chemical and/or electrical signals, but also via microvesicles released into the intercellular space. The present paper, for the first time, provides evidence that Glioblastoma and Astrocyte cells release microvesicles, which carry mitochondrial DNA (mtDNA). These microvesicles have been characterised as exosomes in view of the presence of some protein markers of exosomes, such as Tsg101, CD9 and Alix. Thus, the important finding has been obtained that bonafide exosomes, constitutively released by Glioblastoma cells and Astrocytes, can carry mtDNA, which can be, therefore, transferred between cells. This datum may help the understanding of some diseases due to mitochondrial alterations.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/9125c97484bfcb1003e8b1a679b122ee1d26bf79
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Citations in the corpus
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