Unusual brain growth patterns in early life in patients with autistic disorder

By Eric Courchesne, C. Karns, H. Davis, R. Ziccardi, Ruth A. Carper, Z. Tigue, H. J. Chisum, P. Moses, K. Pierce, Catherine Lord and 6 more. Neurology, 2001

924 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Genetics, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/91771cb253a0c5ba1d57f67fa2b08e2cc1b995a6

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Citations in the corpus

Opportunities in Machine Learning for Healthcare (2018, neutral): “h cancer. This is because the term “T2” is the clinical term forastageofcancerprogression(Winawer et al.,1997),but“T2”alsodescribesoneoutputmodality of MRI that is used to diagnose autism in children(Courchesne et al., 2001). 3 Unique Technical Challenges in Healthcare Tasks In tackling healthcare t”
Early Social Interaction Project for Children With Autism Spectrum Disorders Beginning in the Second Year of Life (2006, result): “The findings on developmental regression are particularly interesting in light of recent brain research studies suggesting that an overgrowth of the brains of children with ASD occurs over the first few years of life (Courchesne et al., 2001; Lainhart et al., 1997; Piven, Arndt, Bailey, & Andreasen,”
Understanding autism: insights from mind and brain. (2003, background): “Importantly, the increased size is not evident from birth, but from ca. 2–4 years (Lainhart et al. 1997; Courchesne et al. 2001).”
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder (2008, background): “Courchesne et al. (2001) suggested that, early on, children with ASD show an anterior–posterior gradient of overgrowth, with the frontal lobe being the largest, although this needs further confirmation.”
A Structural MRI Study of Human Brain Development from Birth to 2 Years (2008, background): “Magnetic resonance imaging confirms that these large heads contain abnormally large brains, reflecting enlargement of gray and white matter (Courchesne et al., 2001; Hazlett et al., 2005).”
Behavioral manifestations of autism in the first year of life (2005, background): “…postnatally, with a unique pattern of acceleration in brain growth as measured by head circumference (Courchesne et al., 2003; Lainhart et al., 1997), which correlates with enlarged grey matter volumes observed in MRI studies by 2–3 years of age (Courchesne et al., 2001; Courchesne et al., 2003).”
Neuroanatomic observations of the brain in autism: a review and future directions (2005, background): “More recently, imaging studies have indicated increased brain volume in autism,most prominent between the ages of 2 and 4.5 years of age, a feature which later appears to plateau during adolescence (Courchesne et al., 2001).”
Face processing occurs outside the fusiform 'face area' in autism: evidence from functional MRI. (2001, background): “…et al., 1993), thinning of the corpus callosum (Piven et al., 1997), abnormal overall brain volume (Piven et al., 1995) and deviant brain growth (Courchesne et al., 2001) noted in both children and adults with autism, suggest that special consideration be taken when interpreting functional…”
The Brain's Default Network (2008, background): “A further consistent observation has been that the amygdala is increased in volume in children with ASD (e.g., Abell et al. 1999, Schumann et al. 2004), perhaps as a reﬂection of abnormal regulation of brain growth (Courchesne et al. 2001).”