Vertebrate MicroRNA Genes

By Lee P. Lim, M. E. Glasner, Soraya Yekta, C. Burge, David P. Bartel. Science, 2003

1,267 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8ffa7b07b74d7a6458827fed30482d87a49942d9

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Citations in the corpus

Computational and experimental identification of C. elegans microRNAs. (2003, methodology): “…in C. elegans has been reported to be feasible (Lee and Ambros, 2001), and a systematic bioinformatic search has been performed in vertebrates (Lim et al., 2003), we present the first systematic examination of C. elegans miRNAs that are conserved in D. melanogaster and H. sapiens as well as…”
MicroRNAs and other tiny endogenous RNAs in C. elegans. (2003, methodology): “... here and elsewhere [8–10, 15] many of the tncRNAs are sensitive to Dicer activity (Tabring the number of known C. elegans miRNA genes to ble 3), and that at least some of them overlap longer 96. Estimates place the total number of worm miRNA ESTs, supports the idea that some tncRNAs are progenes”
A microRNA array reveals extensive regulation of microRNAs during brain development. (2003, background): “In plants, miRNAs have greater complementarity to their mRNA targets, and are likely to trigger the degradation of their targets similarly to the action of small interfering RNAs (siRNAs; Llave et al. 2002; Rhoades et al. 2002).”
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation (2004, methodology): “This study confirms the expression of previously cloned miRNAs [1-3,9,10], and validates the existence of computationally predicted miRNAs [8].”
Modulation of microRNA processing and expression through RNA editing by ADAR deaminases (2006, background): “Numerous small noncoding RNAs, miRNAs involved in RNA-mediated interference (RNAi), have been identifie”
Identifying miRNAs, targets and functions (2012, methodology): “Many algorithms, for example, miRScan [25], miRSeeker [26], miRank [27], miRDeep [28], miRDeep2 [29] and miRanalyzer [30], have been proposed.”
Computational identification of Drosophila microRNA genes (2003, background): “This suggests that nearly 1% of Drosophila genes are miRNAs, a figure that is in relative accord with the percentage recently ascribed to vertebrate genomes [31].”
Metazoan MicroRNAs (2018, background): “Because conserved miRNA genes can be found computationally (Lim et al., 2003) and tend to be expressed at easily detectable levels (Landgraf et al.”