Modulation of microRNA processing and expression through RNA editing by ADAR deaminases

By Weidong. Yang, T. Chendrimada, Qingde Wang, M. Higuchi, P. Seeburg, R. Shiekhattar, K. Nishikura. Nature Structural &Molecular Biology, 2006

840 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6c46750f588ae39434b3b4d19ce3f9abab75fff6

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In Molecular Biology

1. David P. Bartel
2. Scott M. Hammond
3. Thomas Tuschl
4. Phillip D. Zamore
5. M. Siomi
6. Eugene Berezikov
7. John S. Mattick
8. David Baltimore

Citations in the corpus

• MicroRNAs in Common Human Diseases (2012, background): “MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that have attracted tremendous attention from the biological and biomedical research communities over the past decade.”
• MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Nuclear A-to-I editing of miRNA by adenosine deaminase that act on RNA (ADAR) has been implicated in the regulation of miRNA processing [217, 228-231].”
• RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. (2007, background): “Furthermore, certain miRNAs are modified by RNA editing, a process that can lead to changes in miRNA stability or alter their target selection (Kawahara et al., 2007; Knight and Bass, 2002; Yang et al., 2006).”
• Extensive post-transcriptional regulation of microRNAs and its implications for cancer. (2006, background): “Recently, adensosine deaminase (ADAR) editing of specific pri-miRNAs has been reported (Yang et al. 2006).”
• Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. (2010, background): “The latter observation might be due to rapid degradation or impaired processing, which has been shown for miR-142 (Yang et al. 2006) and miR-151 (Kawahara et al.”
• Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “Adenosine-to-inosine (A-to-I) RNA editing of specific pri-miRNAs by ADAR (adenosine deaminase acting on RNA) enzymes prevents their effective processing by Drosha and, in some cases, A-to-I editing directs RNA molecules to Tudor-SN (Tudor staphylococcal nuclease homolog) for degradation (Yang et al.”
• Physiological and pathological roles for microRNAs in the immune system (2010, background): “Adenosine deaminase acting on RNA ( ADAR ; also known as DRADA) expression is upregulated during inflammation and can regulate pri-miRNA processing through mutation of the double-stranded miRNA stem sequenc”
• microRNA regulation of inflammatory responses. (2012, background): “Consequently, studies have found that Adar can edit adenosines in the miRNA primary transcript sequence, affecting processing and target specificity (21).”
• Metazoan MicroRNAs (2018, background): “Another post-transcriptional modification that influences miRNA production is A-to-I editing of pri-miRNAs, which can inhibit primiRNA processing and stimulate pri-miRNA degradation (Yang et al., 2006; Kawahara et al., 2007a).”
• Non-coding RNA. (2006, background): “The maternally transcribed anti-Peg11 transcript is processed into several miRNAs, which cause RISC-mediated cleavage of paternally expressed Rtl1/Peg11 mRNA.”