CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages
By T. Kitamura, Binzhi Qian, D. Soong, Luca Cassetta, R. Noy, Gaël Sugano, Yu Kato, Jiu-feng Li, J. Pollard. Journal of Experimental Medicine, 2015
606 citations recorded by the source corpus.
Kitamura et al. find a role for metastasis-associated macrophage (MAM) chemokine pathways CCL2–CCR2 and CCL3–CCR1 in promoting breast cancer cell pulmonary metastasis. Genetic deletion of CCR1 or CCL3 in a mouse model of breast cancer cell metastasis prevents MAM retention in the lung, reduces MAM-cancer cell interactions and reduces the number of lung metastatic foci.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/43b5a7ee9ac458266af7c9374fef70a99c683393
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Lisa M. Coussens
- J. Pollard
- Luca Cassetta
- D. Gabrilovich
- Elaine Lin
- E. Tcyganov
- Vinit Kumar
- Sima Patel
In Oncology
- J. Pollard
- Lisa M. Coussens
- Luca Cassetta
- D. Gabrilovich
- R. DePinho
- A. Mantovani
- D. Hanahan
- R. Weinberg
Citations in the corpus
- The nature of myeloid-derived suppressor cells in the tumor microenvironment (2016, background): “Monocytes and M-MDSC are actively recruited to primary and metastatic tumor sites [29].”
- Genetics and biology of prostate cancer (2018, background): “TAMs promote tumor progression, migration, and metastasis (Qian and Pollard 2010; Kitamura et al. 2015; Maolake et al. 2017; Linde et al. 2018), and depletion of TAMs has been shown to suppress tumor growth inmultiplemurine tumor models (Luo et al.”
- Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets (2019, methodology): “After 7 days of differentiation monocyte-derived macrophages (MDM) were treated for 24 hr with MDA-MB-231 andMDA-MB-468 cancer cell derived supernatant (CM) as reported in the below sections (Kitamura et al., 2015).”
- Tumor-Associated Macrophages in Tumor Immunity (2020, background): “Indeed, such chemokines do more than attractants do because they activate transcription programs that help macrophages tilt toward the functional of a particular phenotype (12).”