Protective and pathogenic functions of macrophage subsets

By P. Murray, TA Wynn. Nature reviews. Immunology, 2011

5,147 citations recorded by the source corpus.

Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals. They are highly heterogeneous cells that can rapidly change their function in response to local microenvironmental signals. In this Review, we discuss the four stages of orderly inflammation mediated by macrophages: recruitment to tissues; differentiation and activation in situ; conversion to suppressive cells; and restoration of tissue homeostasis. We also discuss the protective and pathogenic functions of the various macrophage subsets in antimicrobial defence, antitumour immune responses, metabolism and obesity, allergy and asthma, tumorigenesis, autoimmunity, atherosclerosis, fibrosis and wound healing. Finally, we briefly discuss the characterization of macrophage heterogeneity in humans.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/9e7d75dbdaa71abbc8abe7cf6eeebfc43688da03

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. R. Locksley
2. S. V. Van Dyken
3. A. Mantovani
4. A. Chawla
5. R. Medzhitov
6. K. Ganeshan
7. P. Italiani
8. D. Boraschi

In Immunology

1. A. Mantovani
2. S. Gordon
3. P. Allavena
4. R. Locksley
5. P. Italiani
6. D. Boraschi
7. S. V. Van Dyken
8. R. Medzhitov

Citations in the corpus

• Mechanisms of fibrosis: therapeutic translation for fibrotic disease (2012, neutral): “…of the wound-healing response, a subset of macrophages converts into a suppressive phenotype that expresses a variety of anti-inflammatory mediators, such as IL-10, Arg1, pr grammed death ligand-2 and Relm-α , which promote wound healing and direct the resolution of the inflammatory response 46 .”
• Mesenchymal stem cell-macrophage crosstalk and bone healing (2018, background): “The general paradigm of macrophage functional polarization in tissue regeneration suggests that M1 macrophages contribute to the initial acute inflammatory stage and clearance of debris from the fracture site, while growth factors secreted by M2 macrophages support MSC-mediated bone formation in the”
• Macrophage Polarization in Inflammatory Diseases (2014, background): “In order to counteract the excessive inflammatory response, macrophages undergo apoptosis or polarize to an M2 phenotype to protect the host from excessive injury and facilitate wound healing [24].”
• Macrophage plasticity, polarization, and function in health and disease (2018, background): “…like aMycobacterium tuberculosis (MTB) might suppress macrophage to avoid cytotoxic functions and evade the cellular immune response or repolarize M1 polarized macrophages toward an M2 phenotype (Bai et al., 2013; Benoit et al., 2008; Kaufmann, 2016; Mege et al., 2011; Murray & Wynn, 2011b).”
• Tissue resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes (2013, background): “Examples of tissue-resident macrophages include liver Kupffer cells, microglia, and peritoneal, lung, splenic red pulp, and bone marrow (BM)macrophages, which by definition reside in and perform homeostatic functions in their respective tissues in the steady state (Murray and Wynn, 2011).”