Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

By B. Molon, S. Ugel, Federica Del Pozzo, C. Soldani, S. Zilio, D. Avella, A. de Palma, P. Mauri, A. Monegal, M. Rescigno and 9 more. Journal of Experimental Medicine, 2011

622 citations recorded by the source corpus.

Blocking CCL2 nitration in tumors promoted CD8+ influx and reduced tumor growth and prolonged survival in mice when combined with adoptive cell therapy.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/374085c1088c19cffaf42c55050cfff9f4bd832b

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Citations in the corpus

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses (2020, background): “In the TME, MDSCs are activated by various molecular factors such as VEGF, GM-CSF, C5a, MMP9, IFN-γ, TGF-β, IL-1β, IL-6, IL-10, IL-12, IL-13, CCL2, CXCL5, CXCL12, gangliosides, and prostaglandins (111).”
Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. (2015, background): “Additionally, nitration reduces binding of antigenic peptides to MHC molecules on tumor cells (25) and blocks T cell migration by nitrating T cell–specific chemokines (26).”
Differential Macrophage Programming in the Tumor Microenvironment (2012, neutral): “In murine tumor models, suppression of CD8+ T cell proliferation by TAMs is at least partly dependent on metabolism of L-arginine via Arginase-1 or inducible nitric oxide synthase (iNOS) [8, 83], and resulting production of oxygen radicals or nitrogen species [84, 85].”
The Metabolic Signature of Macrophage Responses (2019, background): “Peroxynitrite produced by myeloid and tumor cells can nitrate tyrosine residues in the TCR and CD8 receptors, resulting in decreased recognition of peptide–MHC complexes (132) and T cell dysfunction (133); moreover, RNS can induce post-transcriptional modifications of chemokines and thus prevent int”
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors. (2012, neutral): “Apart from reduced expression during malignant transformation, intratumoral chemokines can also be modified by peroxynitrites, which leads to defective recruitment of T cells to tumor islets (19).”
Accessories to the crime: functions of cells recruited to the tumor microenvironment. (2012, neutral): “…murine tumor models, suppression of CD8 + T cell proliferation by TAMs is at least partly dependent on metabolism of L-arginine via arginase-1 or iNOS (Doedens et al., 2010; Movahedi et al., 2010) resulting in production of oxygen radicals or nitrogen species (Lu et al., 2011b; Molon et al., 2011).”
Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy (2014, background): “(29), which showed that CCL2 undergoes posttranslational modification (nitration) within the tumor bed, which makes it less effective in attracting CCR2 cells.”