Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.

By Kathryn A. Moynihan, Andrew A. Grimm, Marie M. Plueger, E. Bernal-Mizrachi, Eric L. Ford, C. Cras-Méneur, M. Permutt, S. Imai. Cell Metabolism, 2005

667 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/8e95703e6c182736b96810ab1902a6b37d820777

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Citations in the corpus

SirT1 gain-of-function increases energy efficiency and prevents diabetes in mice (2008, positive): “SirT1 overexpression in b cells increased insulin secretion (Moynihan et al., 2005).”
Sirtuins in aging and age-related disease. (2006, background): “In a second study, Sirt1 expression was elevated specifically in the mouse pancreas, leading to reduced UCP2 expression and enhanced insulin secretion during glucose stimulation (Moynihan et al., 2005).”
SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “In addition to the regulation of hepatic glucose metabolism, SIRT1 has also been linked to glucose-stimulated insulin secretion in pancreatic -cells (47, 225) (FIGURE 6).”
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan (2008, neutral): “No global correlation with previous studies of SIRT1 overexpression in cultured NIH 3T3 or b cells (Moynihan et al., 2005; Revollo et al., 2004) was observed (data not shown).”
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. (2006, background): “SIRT1 functions as a positive regulator of glucose-stimulated insulin secretion (GSIS) in b cells (Moynihan et al., 2005) by repressing the mitochondrial uncoupling protein UCP-2 (Bordone et al., 2005).”
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. (2007, methodology): “Glucose-Stimulated Insulin Secretion from Primary Islets Islets were isolated by collagenase digestion as described previously (Moynihan et al., 2005).”
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. (2008, background): “Uncoupling protein 2 (UCP-2) expression is induced by AICAR (Jager et al., 2007) and is repressed by SIRT1 in basal conditions (Bordone et al., 2007) (Moynihan et al., 2005).”
Sirtuins as regulators of metabolism and healthspan (2012, background): “As such, SIRT1 deficiency results in high UCP2 levels and diminished insulin secretio”