Physiological functions of thioredoxin and thioredoxin reductase.

By Elias S. J. Arnér, A. Holmgren. European Journal of Biochemistry, 2000

2,547 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8e6d03cee1ff634a301af84fab64df19ad329b19

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Christine H. Foyer
2. Dean P. Jones
3. G. Pastori
4. A. Holmgren
5. M. Jackson
6. S. Powers
7. C. Winterbourn
8. P. Nagy

In Molecular Biology

1. S. Orrenius
2. P. Nagy
3. V. Gogvadze
4. B. Zhivotovsky
5. Christine H. Foyer
6. Elias S. J. Arnér
7. Jun Lu
8. Dean P. Jones

Citations in the corpus

• Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. (2001, background): “Thioredoxin reductase (TrxR) isoenzymes are NADPH-dependent homodimer oxidoreductases with one FAD per subunit that reduce the active site disulfide in oxidized Trx [133,134,152,173].”
• Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. (2014, background): “Oxidized Trx (Trx-S-S) is reduced by a flavoenzyme TrxR and NADPH (122) to its active dithiol form which scavenges ROS and helps maintain proteins in their reduced state (8).”
• Mitochondria, oxidative stress and cell death (2007, background): “Finally, a newly discovered member of the family of GSH-linked mitochondrial redox enzymes is glutaredoxin 2 (Grx2), which was recently cloned and found to be present as both mitochondrial and nuclear isoforms [18].”
• From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health (2007, positive): “TrxR, thioredoxin (Trx), and NADPH constitute the thioredoxin system, a major cellular redox system present in all living organisms (10).”
• NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences (2008, neutral): “antioxidation system—-the thioredoxin system (15).”
• IDENTIFICATION OF STRESS GENE TRANSCRIPTS IN LAMINARIA DIGITATA (PHAEOPHYCEAE) PROTOPLAST CULTURES BY EXPRESSED SEQUENCE TAG ANALYSIS 1 (2005, methodology): “Differentially expressed transcripts in protoplasts and sporophytes were detected by using the significance test established by Audic and Claverie (1997).”
• Reactive oxygen species in cancer (2010, background): “In its active state, thioredoxin scavenges reactive oxygen species and keeps proteins in their reduced state [45].”
• Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology (2017, background): “The maintenance of an appropriate redox balance is particularly important for the activity of key proteins (Arner and Holmgren, 2000; Meyer et al., 2009; Hanschmann et al., 2013).”
• Drought and Salt Tolerance in Plants (2005, background): “Their involvement in the response to oxidative stress is well documented in bacteria, yeast, and animal cells ( Arner and Holmgren, 2000 ).”
• Oxidative Stress in Aging Human Skin (2015, background): “an important role in the protection against oxidative stress since it prevents intra- and intermolecular formation of disulfide bonds which would otherwise lead to the inactivation and/or aggregation of these proteins [194].”