Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization.

By K. Laulagnier, C. Motta, S. Hamdi, Sébastien Roy, F. Fauvelle, J. Pageaux, Toshihide Kobayashi, J. Salles, B. Perret, C. Bonnerot and 1 more. Biochemical Journal, 2004

623 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8e11a3aa04c72955519455ba99a642ad7da700ce

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Citations in the corpus

Lipids in exosomes: Current knowledge and the way forward. (2017, background): “It should be mentioned that PLD2 has earlier been reported to be associated with exosomes, and its activity correlates with the amounts of exosomes released from the mast cell line RBL-2H3 [83].”
Exosomal-like vesicles are present in human blood plasma. (2005, background): “The lipid composition of exosomes reveals an enrichment in cholesterol, sphingomyelin and gangliosid GM3 levels (24, 27 ).”
Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, neutral): “Extensive evaluation from different cell types, such as hematopoietic cells, cancer cells, internal MVBs, etc., have shown that exosomes carry lipids that are enriched in lysobisphosphatidic acid; a key moiety in exosome biogenesis pathway that interacts strongly with another exosome biogenesis prot”
Exosome Function: From Tumor Immunology to Pathogen Biology (2008, background): “The typical lipid composition of mast cell-derived exosomes includes lysophosphatidylcholine, sphingomyelin, phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, cholesterol and diglyceride (34).”
Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. (2012, neutral): “[20] also found that,”
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis (2011, background): “Exosomes have a membrane topology that is similar to the plasma membrane, but previous studies have shown that exosomes contain phosphatidylserine facing the extracellular environment (Fomina et al., 2003; Laulagnier et al., 2004; Miyanishi et al., 2007; Morelli et al., 2004).”
ExoCarta 2012: database of exosomal proteins, RNA and lipids (2011, background): “Lipid composition analysis have been performed with exosomes derived from dendritic cells (19), basophilic leukemia cells (20), mast cells (19), reticulocytes (21) and B cells (22).”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “Fewer studies have analyzed the lipid composition of exosomes (Laulagnier et al. 2004b, Llorente et al. 2013, Trajkovic et al. 2008, Wubbolts et al. 2003).”
Biodistribution and Delivery Efficiency of Unmodified Tumor-Derived Exosomes (2014, methodology): “Liposomes in this work were prepared to either mimic the lipid composition of exosomes (SynExoLiposomes) [24,28–32], or to be comparable to a widely studied liposomal formulation, PC:Chol.”