ExoCarta 2012: database of exosomal proteins, RNA and lipids

By Suresh Mathivanan, Cassie J. Fahner, G. E. Reid, Richard J. Simpson. Nucleic Acids Res., 2011

1,029 citations recorded by the source corpus.

Exosomes are membraneous nanovesicles of endocytic origin released by most cell types from diverse organisms; they play a critical role in cell–cell communication. ExoCarta (http://www.exocarta.org) is a manually curated database of exosomal proteins, RNA and lipids. The database catalogs information from both published and unpublished exosomal studies. The mode of exosomal purification and characterization, the biophysical and molecular properties are listed in the database aiding biomedical scientists in assessing the quality of the exosomal preparation and the corresponding data obtained. Currently, ExoCarta (Version 3.1) contains information on 11 261 protein entries, 2375 mRNA entries and 764 miRNA entries that were obtained from 134 exosomal studies. In addition to the data update, as a new feature, lipids identified in exosomes are added to ExoCarta. We believe that this free web-based community resource will aid researchers in identifying molecular signatures (proteins/RNA/lipids) that are specific to certain tissue/cell type derived exosomes and trigger new exosomal studies.

Subfields: Cancer Research, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/107e98602c1be84b1654d6a1b241b7c97a94c71f

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Citations in the corpus

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions (2012, background): “derived from various cell types (as listed in the ExoCarta database (42)).”
Exosomes in cancer development, metastasis, and immunity (2019, background): “org/) lists thousands of proteins, mRNAs, and miRNAs that are candidate exosomes cargos [46], but the cargos vary in different cell lines.”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “Three different databases are publicly accessible: Exocarta, Vesiclepedia, and EVpedia (Kim et al. 2013; Kalra et al. 2012; Mathivanan and Simpson 2009; Simpson et al. 2012; Mathivanan et al. 2012).”
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation (2012, neutral): “org), a database for molecular data (proteins, RNA, and lipids) identified in exosomes, catalogs only exosomal studies (as reported by the authors) [31].”
Plasma Proteome Database as a resource for proteomics research: 2014 update (2013, background): “There are 318 EV proteins annotated in PPD and each is linked to Exocarta and Vesiclepedia, both manually curated resources for proteins, messenger RNA, micro RNA and lipids reported from EVs including exosomes (42,43).”
Bovine milk-derived exosomes for drug delivery (2015, neutral): “1F), in agreement with reported values [13, 22].”
Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. (2012, background): “Exosome Homogenous population with a size of 40–100 nm in diameter End of endocytic pathway, released from cells when multivesicular bodies fuse with the plasma membrane (16,103,117)”
Optimized exosome isolation protocol for cell culture supernatant and human plasma (2015, methodology): “This was also seen when the abundance of the canonical exosome protein Flotillin-1 (9,10) was assessed (Fig.”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “Uptake mechanisms Due to their extensive and variable protein content, EVs may be considered as vectorial signalosomes (92).”