A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism.

By B. Samuel, Jeffrey I. Gordon. Proceedings of the National Academy of Sciences of the United States of America, 2006

627 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/8df45d8e0a970493ba439a57f4d82efd5cbe25b8

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In Nutrition and Dietetics

Citations in the corpus

Effects of Gut Microbes on Nutrient Absorption and Energy Regulation (2012, background): “For instance, germ-free mice colonized with B theta with and without M smithii showed increased energy harvest and greater adiposity in the mice co-colonized with B theta and M smithii.(42) Samuel and Gordon,(42) Samuel et al,(96) and Hansen et al(135) suggested that targeting hydrogen-consuming spe”
Development of the Human Infant Intestinal Microbiota (2007, background): “In addition, progressive changes in the gut environment, due to intrinsic developmental changes in the gut mucosa, transition to an ‘‘adult’’ diet, and the effects of the microbiota itself [44,49–51], may impose increasingly stringent selection for the most highly adapted bacteria.”
Shifting the balance: antibiotic effects on host–microbiota mutualism (2011, background): “These ecological interactions have been demonstrated in colonization models involving prominent members of the intestinal microbiot”
Monitoring Bacterial Community of Human Gut Microbiota Reveals an Increase in Lactobacillus in Obese Patients and Methanogens in Anorexic Patients (2009, background): “Methanobrevibacter associated with Bacteroides thetaiotaomicron led to weight gain in gnotobiotic mice [3].”
Gut Microbiome: Profound Implications for Diet and Disease (2019, background): “smithii has been shown to increase host adiposity by directing Bacteroides thetaiotaomicron to ferment plant polysaccharides (fructans) in the diet to the SCFA acetate [257].”
Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota (2007, background): “Conversely, the microbiota optimizes nutrient utilization [3,4], and boosts maturation of intestinal tissues”
Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. (2015, methodology): “We found that the abundance of methanogens was higher after BKB ingestion in the responders compared with the non-responders (Figure S2D), which could contribute to the increased efficiency of polysaccharide fermentation in these individuals (Samuel and Gordon, 2006; Zhang et al., 2009).”
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 (2008, methodology): “The density of colonization was determined in cecal contents using qPCR assays that used species-specific primers (8).”
Interplay between the human gut microbiome and host metabolism (2019, background): “intestinalis) were present in at least 80% of the population and are already known for their ability to affect gut lumen metabolism [19,20,21,22].”
Specificity of polysaccharide use in intestinal Bacteroides species determines diet-induced microbiota alterations (2010, positive): “Bt increases expression of this PUL in vivo while downregulating the vast majority of other PULs when bi-associated in the gnotobiotic mouse intestine with the methanogenic archeon, Methanobrevibacter smithii (Samuel and Gordon, 2006).”