Effects of Gut Microbes on Nutrient Absorption and Energy Regulation

By Rosa Krajmalnik-Brown, Z. Ilhan, Dae-Wook Kang, J. DiBaise. Nutrition in clinical practice, 2012

754 citations recorded by the source corpus.

Malnutrition may manifest as either obesity or undernutrition. Accumulating evidence suggests that the gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet. The composition of the gut microbiota has been shown to differ between lean and obese humans and mice; however, the specific roles that individual gut microbes play in energy harvest remain uncertain. The gut microbiota may also influence the development of conditions characterized by chronic low-level inflammation, such as obesity, through systemic exposure to bacterial lipopolysaccharide derived from the gut microbiota. In this review, the role of the gut microbiota in energy harvest and fat storage is explored, as well as differences in the microbiota in obesity and undernutrition.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/fa0239634ed245f4a04e6d75e2580c55bafd286d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Sander Rensen
2. S. Pesoa
3. L. Gauthier
4. A. Zazueta
5. F. Magne
6. C. Dejong
7. Ramadass Balamurugan
8. M. Gotteland

In Physiology

1. Sander Rensen
2. C. Dejong
3. E. Neis

Citations in the corpus

• The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients? (2020, result): “Based on these results and others obtained from obese animals and humans [13,20–25], it has been proposed that the Firmicutes were more effective in extracting energy from food than Bacteroidetes, thus promoting a more efficient absorption of calories and the subsequent weight gain [25].”
• Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population (2017, background): “A possible explanation for our findings is that Firmicutes are more effective as an energy source than Bacteroidetes, thus promoting more efficient absorption of calories and subsequent weight gain [5, 6].”
• Impact of Omega-3 Fatty Acids on the Gut Microbiota (2017, background): “The resultant postprandial endotoxemia leads to low-grade systemic inflammation, which has been implicated in the development of several metabolic diseases, insulin resistance, adipocyte hyperplasia and reduction of pancreatic β-cell function [46], and impaired glucose metabolism [47].”
• The Role of Microbial Amino Acid Metabolism in Host Metabolism (2015, background): “In addition, intestinal bacteria are known to have a major impact on nutrient absorption [6,71,100].”