Granule-Like Neurons at the Hilar/CA3 Border after Status Epilepticus and Their Synchrony with Area CA3 Pyramidal Cells: Functional Implications of Seizure-Induced Neurogenesis

By H. Scharfman, J. Goodman, Anne L. Sollas. Journal of Neuroscience, 2000

615 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/8dabb68e307e8f901736492de0c76b273051d292

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Citations in the corpus

Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “The presence of these hilar basal dendrites on dentate granule cells as well as ectopic hilar granule cells after seizures could lead to a recurrent excitatory circuitry (Ribak et al., 2000; Scharfman et al., 2000).”
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling (2007, methodology): “These studies suggested that seizure activity accelerated the early stages of neuronal maturation and that a fraction of hippocampal granule cells generated in response to seizures displayed aberrant basal dendrites or was ectopically localized within the hilar/CA3 border (Parent et al., 1997; Schar”
A hypothesis about the role of adult neurogenesis in hippocampal function. (2004, background): “Ectopic neurons at the hilar-CA3 border can be readily recognized by their morphology and electrical properties (37), i.”
Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment (2002, background): “As more studies support the view that adult hippocampal neurogenesis is involved in hippocampal function, theories arise that link a failure of neurogenic regulation to hippocampal pathology, most notably major depression and temporal lobe epilepsy with ammons horn sclerosis.(18,19) Suggestive links”
Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients. (2007, background): “In some animal models of epilepsy (systemic pilocarpine or kainate injection), a transient stimulation of dentate neurogenesis has been reported (Parent et al., 1997; Scharfman et al., 2000; and others), but in these models, no granule cell dispersion occurs.”
Seizures Accelerate Functional Integration of Adult-Generated Granule Cells (2006, positive): “For example, after epileptogenesis, some newborn cells migrate into the hilus where aberrant connectivity promotes synchronous discharges with surviving CA3 pyramidal cells (Scharfman et al., 2000; Scharfman, 2004).”
Pattern separation in the hippocampus through the eyes of computational modeling (2017, background): “In such cases, the effect on pattern separation as predicted with computational modeling would be severe (Scharfman et al., 2000, 2007) due to overly increased excitability.”
Spatial firing correlates of physiologically distinct cell types of the rat dentate gyrus (2012, background): “, 1993) and eventually stop spiking in response to excitatory stimuli (Scharfman, 1992; Williamson et al., 1993; Scharfman et al., 2000).”
Pattern Separation in the Dentate Gyrus: A Role for the CA3 Backprojection (2010, background): “…cells that are born in postnatal life, because such granule cells may be targets of the backprojection, although this may only occur when new granule cells are slightly ectopic or develop a basal dendrite located in the hilus (Scharfman et al., 2000; Scharfman, 2004; Scharfman and Gray, 2007).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “Specifically, it has been suggested that neuronspecific progenitors, with a restricted capacity for self-renewal, generate new neurons in the adult dentate gyrus (Seaberg & van der Kooy 2002).”
Doublecortin expression levels in adult brain reflect neurogenesis (2005, background): “Surprisingly, some neuroblasts migrate in chains from the dentate gyrus towards abnormal locations such as the hilus (Scharfman et al., 2000).”