Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment

By Gerd Kempermann, D. Gast, Fred H. Gage. Annals of Neurology, 2002

899 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/bd2f16fc6e27315606fd2081cf57159036f0b402

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Adult neurogenesis: from precursors to network and physiology. (2005, background): “In this study, the improvement in learning parameters observed after enrichment was suggested to be aspecific, resulting from better adaptive skills in exploration, greater locomotor aptitude, and endurance following enrichment, leading the authors to suggest that the contribution of adult hippocamp”
Learning-Induced Survival of New Neurons Depends on the Cognitive Status of Aged Rats (2007, background): “It has been shown that exposure of middle-aged or senescent animals to an enriched environment increases spatial memory abilities and neurogenesis (Kempermann et al., 1998, 2002).”
Inhibition of neurogenesis interferes with hippocampus‐dependent memory function (2006, background): “In other experiments, exposure to an enriched environment (Kempermann et al., 2002) or running activity (van Praag et al., 1999a) increased hippocampal neurogenesis and also led to improved performance on a water-maze test of spatial memory; a test that is considered to be highly sensitive to…”
Functional significance of adult neurogenesis. (2004, background): “Adult neurogenesis decreases with increasing age, but in relative terms a much stronger induction is possible in the aged than in the young hippocampus [39].”
Neuroprotective effects of estradiol in hippocampal neurons and glia of middle age mice. (2007, background): “A typical feature of aging is the reduction of hippocampal neurogenesis (Cameron and McKay, 1999; Kuhn et al., 1996; Kempermann et al., 2002; Heine et al., 2004).”
The need to understand the behaviour of fish reared for mariculture or restocking (2006, background): “…mammals has already demonstrated that increasing complexity of the captive environment increases both behavioural and neuronal plasticity, improves cognitive performance, and increases survival of reintroduced species (Hunter et al., 2002; Kempermann et al., 2002; Bredy et al., 2003; Rabin, 2003).”
Exposure to variable spatial information in the early rearing environment generates asymmetries in social interactions in cod (Gadus morhua) (2005, positive): “…referred to as environmental enrichment, can increase both behavioural and neuronal plasticity, improve cognitive performance, and that together these ultimately improve the survival chances of the re-introduced species (Hunter et al. 2002; Kempermann et al. 2002; Bredy et al. 2003; Rabin 2003).”
Transient expression of doublecortin during adult neurogenesis (2003, background): “Please note that the increased speckled green fluorescence in aged animals is due to deposits of the aging pigment lipofuscin (Landfield et al., 1981; Kempermann et al., 2002).”
Training-Induced Brain Structure Changes in the Elderly (2008, background): “Interestingly, these findings have been replicated in older and aged animals (Kempermann et al., 2002), suggesting that age is not per se a limiting factor for structural plasticity.”
Enrichment promotes learning in fish (2010, background): “In mammals and birds, complex environments stimulate the development of neural tissue, cognitive performance and flexible behaviour (Hunter et al. 2002, Kempermann et al. 2002, Bredy et al. 2003, Rabin 2003).”