Cancer epigenomics: DNA methylomes and histone-modification maps

By Manel Esteller. Nature reviews genetics, 2007

2,210 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8c4c3dfbbdfe636999a267f0a7e88a8d0e33d8e6

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Citations in the corpus

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine (2008, background): “Hypermethylation-induced gene silencing of tumor suppressor and other cancer-related genes plays a fundamental role in human tumorigenesis.(15) The reversion of these epigenetic mutations can therefore restore proliferation control and apoptosis sensitivity.”
Current and Future Development in Lung Cancer Diagnosis (2021, background): “DNA methylation and histone modification modulate gene expression that could influence early lung cancer detection [47].”
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, positive): “DNA Demethylation and Cancer Aberrant DNA methylation is one of the hallmarks associated with cancer cells (Baylin and Jones, 2011; Esteller, 2007).”
Epigenetic Determinants of Cancer. (2016, background): “The most well-understood mechanism by which DNA methylation contributes to cancer is through association with the focal hypermethylation of promoters at TSGs.”
Cancer Genetics and Epigenetics: Two Sides of the Same Coin? (2012, background): “Mutations or translocations of these genes are observed in colon, 14 Cancer Cell 22, July 10, 2012 ª2012 Elsevier Inc. uterine, and lung tumors and in leukemias (Esteller, 2007).”
DNA methylation and cancer. (2010, background): “Thus, regulation of packaging of DNA ensures maintenance of correct chromosome replication, gene expression, and stable gene silencing (Esteller, 2007).”
Hallmarks of cancer: the next generation. (2011, positive): “, inactivation of tumor suppressor genes, can also be acquired through epigenetic mechanisms such asDNAmethylation and histonemodifications (Berdasco and Esteller, 2010; Esteller, 2007; Jones and Baylin, 2007), some clonal expansions may well be triggered by nonmutational changes affecting the regul”
SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips (2012, background): “Changes in DNA methylation are vital for normal development and differentiation [1], whilst aberrant methylation is involved in diseases such as diabetes, schizophrenia, multiple sclerosis and cancer [2-4].”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “Generally, in diseased tissues, ncRNAs are dysregulated as a consequence of genomic structural and copy number variations, epigenetic modifications or transcription factor alterations 99,100 .”
A microRNA DNA methylation signature for human cancer metastasis (2008, background): “In classical tumor suppressor genes, promoter CpG island hypermethylation occurs in genes involved in cell adherence, invasion, and angiogenesis, such as cadherins, tissue inhibitors of metalloproteinases, and thrombospondins (18).”