Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

By Carlo Stresemann, F. Lyko. International Journal of Cancer, 2008

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Integrating virtual screening and combinatorial chemistry for accelerated drug discovery. (2011, background): “These two drugs are nucleoside analogues, which after incorporation into DNA, cause covalent trapping and subsequent depletion of DNA methyltransferases [55, 56].”
Mapping and elucidating the function of modified bases in DNA (2017, background): “For example, the ribo- and deoxyribonucleoside analogues of 5-azacytidine are currently used in the clinic to treat cancer including leukemia.(114) They are thought to become phosphorylated on three sites before being incorporated into genomic DNA during replicative DNA synthesis.”