An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation

By Min Gyu Lee, Christopher Wynder, Neil Cooch, R. Shiekhattar. Nature, 2005

829 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7ae30e08df5f40379d109ac187a574f5e7eaea9f

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In Molecular Biology

1. Yi Zhang
2. Yang Shi
3. J. Whetstine
4. K. Helin
5. A. Shilatifard
6. Xiang-Jiao Yang
7. J. Christensen
8. E. Seto

Citations in the corpus

• LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. (2009, background): “(C) Equal amounts of HeLa cellular extracts were coimmunoprecipitated with antibodies against Mi-2 or CoREST, respectively.”
• JmjC-domain-containing proteins and histone demethylation (2006, background): “Full enzymatic activity of LSD1 requires its association with other proteins, such as the CoREST (restin corepressor) complex, indicating that regulatory subunits can have a role in modulating demethylase activit”
• The complex language of chromatin regulation during transcription (2007, background): “Two classes of lysine demethylase have recently been identified: the LSD1/BHC110 class (which removes H3K4me1 and me2”
• The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways (2022, background): “HMG20A is a paralogue of HMG20B (also called BRAF35), a core subunit of the LSD1/Co-REST complex (2,3).”
• The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men (2008, background): “The CoREST complex promotes nucleosomal deacetylation through its SANT domain”
• Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (2006, background): “The LSD1 protein interactions have also been shown to play a key role in either facilitating or inhibiting demethylation of more complex substrates (Lee et al., 2005; Shi et al., 2005).”
• Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. (2008, background): “Gene location analysis demonstrated that LSD1 and BHC80 binding were interdependent, leading to the suggestion that the binding of BHC80 to demethylated K4 may constitute a targeting system leading to the propagation of K4 demethylation and required for the binding of LSD1 (Lan et al. 2007b).”
• Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions (2006, neutral): “Recently, lysine-specific demethylase 1 (LSD1) has been demonstrated to remove dimethyl groups from Lys4 or Lys9 of histone H3 (refs”