Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

By T. Samad, K. Moore, A. Sapirstein, Sara Billet, A. Allchorne, S. Poole, Joseph V. Bonventre, Clifford J. Woolf. Nature, 2001

1,322 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/8b612631bb82a199cc215f6b44b8d6d1afd0d9e8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Ji
2. Clifford J. Woolf
3. Alban Latremoliere
4. Arne May

In Pharmacology

1. Clifford J. Woolf
2. R. Ji
3. Alban Latremoliere
4. J. Tschopp
5. G. Moalem-Taylor
6. P. Austin
7. Jürgen Sandkühler
8. Linda R. Watkins

In Physiology

1. Clifford J. Woolf
2. R. Ji
3. Alban Latremoliere
4. J. Tschopp
5. G. Moalem-Taylor
6. P. Austin
7. Jürgen Sandkühler
8. Arne May

Citations in the corpus

• Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition (2004, background): “Bacterial LPS from infecting organisms, or circulating IL-1, stimulate the expression of COX-2 and of PGE synthase in endothelial cells that constitute the blood-brain barrier (Ek et al., 2001; Samad et al., 2001).”
• Central sensitization: Implications for the diagnosis and treatment of pain (2010, background): “A COX-2 inhibitor does have efficacy though if the central sensitization is triggered by peripheral inflammation [225], as predicted by pre-clinical models [189].”
• Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord (2008, background): “, 2002) and Cox-2 (Samad et al., 2001; Ji et al., 2003).”
• Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity (2009, positive): “A critical central pathway for the generation of inflammatory pain hypersensitivity involves induction of cyclooxygenase-2 (Cox-2) in dorsal horn neurons, to drive production of prostaglandin E2 (PGE2).(269,349) PGE2 binds to its EP2 GPCR on dorsal horn neurons to potentiate AMPAR and NMDAR currents”
• Natural forms of vitamin E: metabolism, antioxidant and anti-inflammatory activities and the role in disease prevention and therapy (2014, neutral): “For instance, prostaglandin E2 (PGE2), which is produced from COX-1- and COX-2-catalyzed oxidation of AA, is believed to cause pain and fever [74,76], as well as activating cytokine formation [77].”
• Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved (2007, background): “In rodents, analysis of these inflammatory mediators in the context of CNS injury suggests that some of these molecules could increase sensitivity to pain (Samad et al., 2001; Miller, 2005).”