Stem Cells Units of Development, Units of Regeneration, and Units in Evolution

By Irving L. Weissman. Cell, 2000

1,954 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8b48a1abbdf61fc967253a421a6f8006f45a6675

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Citations in the corpus

Embryo-derived stem cells: of mice and men. (2001, positive): “…results that include the presence of reservoirs of tissue-specific stem cells in favorable ectopic locations such as the bone marrow, persistence of rare pluripotent stem cells in privileged sites, and interconversion of stem cells in response to some external insult or stimulation (Weissman 2000).”
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, neutral): “In this capacity, stem cells qualify as fundamental “units of development” (61) because they can incipiently seed developing tissues anew.”
Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. (2002, neutral): “Cells in most if not all tissues are hierarchically organized with regard to their proliferative and differentiation potential (1).”
Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. (2001, neutral): “HEMATOPOIETIC STEM CELLS AS THE MODEL Stem cells are currently defined as single cells that are clonal precursors of both more stem cells of the same type, as well as a defined set of differentiated progeny (for reviews, see Gage 2000; Weissman 2000a,b).”
Myogenic satellite cells: physiology to molecular biology. (2001, positive): “Progenitor cells that are resident in other adult tissues have stem cell characteristics, as they are capable of self-renewal and multilineage differentiation along a specified molecular pathway (61, 194, 195).”
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. (2003, positive): “Indeed, the similarities between cancer cells and normal stem cells, such as increased proliferation potential and self-renewal ability, were noticed decades ago (Rudland et al. 1997; Weissman 2000).”
Cancer stem cells in nervous system tumors (2004, neutral): “Relationship between neural stem cells (NSCs) and cancer stem cells Stem cells are functionally defined as self-renewing, multipotent cells that exhibit multilineage differentiation (Fuchs and Segre, 2000; Weissman, 2000; Reya et al., 2001).”
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, positive): “are in G0. As expected, MPPs expressing CD48 and CD135 are highly proliferative (26% S + G2/M and 16% G0 )( Figure 1B) (Adolfsson et al., 2001; Weissman, 2000; Wilson et al., 2007).”
Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. (2006, positive): “This clonal model of heartlineage diversification would be analogous to hematopoiesis, in which a single hematopoietic stem cell can generate all of the blood-cell lineages (Morrison and Weissman, 1994; Weissman, 2000 ).”
The Evolving Concept Review of a Stem Cell: Entity or Function? (2001, positive): “More recently, after intravascular in- Ramos et al., 2000; Woodbury et al., 2000). jection into lethally irradiated rodents, the SP fraction of BM-derived cells reconstituted the blood, was incor- Criteria for Establishing the Occurrence porated into ischemically damaged myocardium, and of Cell…”