Biological principles of microRNA-mediated regulation: shared themes amid diversity
By A. Flynt, Eric C. Lai. Nature reviews genetics, 2008
815 citations recorded by the source corpus.
Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic development and physiology. Amidst an extensive regulatory web that is predicted to involve thousands of transcripts, emergent themes are now beginning to illustrate how microRNAs have been incorporated into diverse settings. These include potent inhibition of individual key targets, fine-tuning of target activity, the coordinated regulation of target batteries, and the reversibility of some aspects of microRNA-mediated repression. Such themes may reflect some of the inherent advantages of exploiting microRNA control in biological circuits, and provide insight into the consequences of microRNA dysfunction in disease.
Subfields: Cancer Research, Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/51efd995d035094d8dbdbeaf188c080b9b5503ca
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Citations in the corpus
- Evolution and Functional Diversification of MIRNA Genes (2011, background): “The importance of miRNA-mediated regulation is evident by the severe pleiotropic phenotypes in miRNA-deficient mutants (Park et al., 2002; Reinhart et al., 2002; Jones-Rhoades and Bartel, 2004; Sunkar and Zhu, 2004; Flynt and Lai, 2008).”
- Evolution of microRNA diversity and regulation in animals (2011, background): “The details of the organization and functions of miRNA networks have been extensively reviewed elsewher”
- UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs (2009, background): “Such regulation is mostly mediated by cis-acting elements located in the 50 and 30 untranslated regions of mRNAs (50UTR and 30UTR) (1) and miRNAs interacting with their specific targets in 30UTRs (2,3).”
- Origin, biogenesis, and activity of plant microRNAs. (2009, neutral): “A function for miRNAs as safeguards against unwanted gene expression is a common theme in metazoans (Flynt and Lai, 2008), but this concept has not yet received as much attention in plants.”