Asymmetric cell divisions promote stratification and differentiation of mammalian skin

By T. Lechler, Elaine Fuchs. Nature, 2005

1,055 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8919490917979d25fc6eba19bc053ef438a56c9c

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Citations in the corpus

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “In skin epithelium, β1 integrins mediate adhesion of basal keratinocytes to the underlying basement membrane and govern stem cell renewal by regulating cell-cycle progression and by determining the axis of polarity for asymmetric cell division (Lechler and Fuchs, 2005; Taddei et al., 2008).”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “The divisions of fetal progenitors in the nervous system (Gotz and Huttner, 2005) and skin (Lechler and Fuchs, 2005) have been analyzed, suggesting that these early progenitors undergo symmetric and asymmetric divisions during the course of organogenesis.”
Asymmetric self-renewal and commitment of satellite stem cells in muscle. (2007, background): “By contrast, stem cell divisions in an apical-basal orientation are asymmetric and give rise to a stem cell at the basal surface and a committed daughter cell destined for differentiation on the apical surface (Fuchs et al., 2004; Knoblich, 2001; Lechler and Fuchs, 2005).”
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling (2010, background): “Stem cells in other epithelial systems, such as the skin, characteristically maintain basal lamina contac”
The aPKC–PAR-6–PAR-3 cell polarity complex localizes to the centrosome attracting body, a macroscopic cortical structure responsible for asymmetric divisions in the early ascidian embryo (2006, background): “, 2004), whereas in epithelial cells it appears that LGN/Pins links the PAR complex to the microtubule-associated protein NuMA (Du and Macara, 2004; Lechler and Fuchs, 2005).”
Asymmetric and symmetric stem-cell divisions in development and cancer (2006, background): “This lack of flexibility is a problem, given that stem-cell numbers can increase markedly, both when stem-cell pools are first established during developmen”
Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells (2009, background): “At E14, epidermis consists of a basal layer of progenitors and a layer of suprabasal cells that have initiated a program of terminal differentiation but are still proliferative (Figures S1A and S1B available online) (Lechler and Fuchs, 2005; Watt et al., 2006).”
Bone-marrow haematopoietic-stem-cell niches (2006, background): “However, only a few examples of divisional asymmetry have been documented in higher vertebrate”
No place like home: anatomy and function of the stem cell niche (2008, background): “Orientated stem cell divisions have also been described in the mammalian epitheliu”
Cadherins and cancer: how does cadherin dysfunction promote tumor progression? (2008, background): “A requirement for a functioning cadherin–catenin complex is also suggested by studies in mice, where conditional knockout of a-catenin caused mislocalization of LGN, Par3 and aPKC (Lechler and Fuchs, 2005).”
Epidermal stem cells of the skin. (2006, background): “F or p er so na l u se o nl y. explained by a mechanism whereby basal cells divide asymmetrically relative to the basement membrane to maintain a proliferative daughter and give rise to a differentiating daughter cell overlying it (Lechler & Fuchs 2005).”
Mechanisms of stem cell self-renewal. (2009, background): “Mammalian stem cells employ similar mechanisms to self-renew asymmetrically in the central nervous system, in the basal layer of the epidermis, in skeletal muscle, and in other tissues (Huttner & Kosodo 2005, Kuang et al. 2007, Lechler & Fuchs 2005).”