Asymmetric and symmetric stem-cell divisions in development and cancer

By S. Morrison, J. Kimble. Nature, 2006

1,484 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/891403450bb7269a00f7fc28e8ec5f2cffb620a3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. S. Morrison
2. Hans Clevers
3. Elaine Fuchs
4. M. Clarke
5. Y. Hsu
6. Hugo J. G. Snippert
7. H. Pasolli
8. A. Spradling

In Oncology

1. Hans Clevers
2. S. Morrison
3. Elaine Fuchs
4. Dalong Qian
5. Y. Shimono
6. M. Clarke
7. N. Lobo
8. Hugo J. G. Snippert

Citations in the corpus

• In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. (2007, methodology): “enhanced neurogenesis by testing two hypotheses (reviewed in Morrison and Kimble, 2006 ).”
• Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “viding asymmetrically under steady-state conditions retain the capability to divide symmetrically to restore stem cell pools depleted by injury or disease [19].”
• Satellite cells and the muscle stem cell niche. (2013, background): “Although asymmetric self-renewal may be sufficient under physiological conditions, satellite stem cells may favor symmetric self-renewal divisions to replenish and expand their population in response to acute need for a large number of satellite cells after injury or disease state (354).”
• Tracking adult stem cells (2011, background): “In the steady state, asymmetrical division—if executed perfectly—would allow stem cells to maintain their numbers while sustaining the production of transit-amplifying daughter cells”
• EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. (2008, background): “It is also possible that heterogeneity, a feature of cancer stem cells ( 38 ), may exist in these types of tumors because both hepatoblastoma subtype HCC and HpSC-HCC are considered to be evolved from hepatic stem cells.”
• The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. (2009, background): “Notably, some of the genes that control asymmetric cell divisions in fly have an evolutionarily conserved role in the regulation of cell polarity and in tumor suppression (Morrison and Kimble, 2006), suggesting that polarity loss may contribute causally to cancer in mammals.”
• Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth (2011, positive): “However, we show that differentiation of MSCs into aSMA+ cells is a normal pattern of differentiation in vitro and in vivo, compatible with asymmetric stem cell division in a broad definition, although more specification regarding an intrinsic or extrinsic mechanism would be needed (Morrison and Kim”
• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Cell 132, 598–611, February 22, 2008 ª2008 Elsevier Inc. 605 is likely to be constitutively used as a way of sustaining the niche (Morrison and Kimble, 2006).”
• Dynamics Between Stem Cells, Niche and Progeny in the Hair Follicle (2011, positive): “During normal homeostasis, they often exit from their niches and progress to become transit-amplifying (TA) cells, undergoing a series of rapid divisions before committing to terminal differentiation (Fuchs, 2009; Morrison and Kimble, 2006).”
• The therapeutic promise of the cancer stem cell concept. (2010, background): “In addition, such stem cells possess the capacity to proliferate extensively (1), for example, in response to injury and during development (2).”