Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex

By A. Jeffreys, L. Kauppi, R. Neumann. Nature Genetics, 2001

870 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/88d5713843e956ff9dec30871abf1670f7f9e863

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Citations in the corpus

High-resolution haplotype structure in the human genome (2001, background): “, and the same observation of inhomogeneity of recombination is made for the class II region of the MHC elsewhere in this issu”
Haplotype tagging for the identification of common disease genes (2001, background): “, can be tagged with 4–6 SNPs, provided the 'hot spot' of recombination in the gene is taken into accoun”
Beans (Phaseolus spp.) – model food legumes (2004, background): “Most of the recent published studies on LD on a genome-wide analyses have been conducted in a limited number of species, including humans (Daly et al. 2001; Jeffreys et al. 2001), Drosophila pseudoobscura (Schaeffer et al.”
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. (2004, background): “A small number of recombination hotspots have been confirmed (Chakravarti et al. 1984; Jeffreys et al. 2001), and some analyses have suggested the presence of recombination hotspots between blocks, but simulations with uniform recombination rates have also been shown to generate " blocks "…”
Interrogating a high-density SNP map for signatures of natural selection. (2002, background): “However, several recent studies indicate that the distribution of recombination is highly punctuated and can vary substantially across genomic regions (Daly et al. 2001; Jeffreys et al. 2001).”
Structure of linkage disequilibrium in plants. (2003, background): “(24) documented the relationship between LD decay and hot spots in recombination for the major histocompatibility complex (MHC) in humans.”
Calibrating a coalescent simulation of human genome sequence variation. (2005, background): “…recombination to obtain sufficient extent of LD is consistent with a range of observations indicating non-uniform recombination in the human genome (Jeffreys et al. 2001; Cullen et al. 2002; May et al. 2002; Reich et al. 2002; Kauppi et al. 2003; Wall and Pritchard 2003a,b; Crawford et al. 2004;…”
Impact of selection, mutation rate and genetic drift on human genetic variation. (2003, background): “Recombination hot spots have been hypothesised to contribute greatly to the heterogeneity in polymorphism density along the genome (11-15).”
Approximate likelihood methods for estimating local recombination rates (2002, methodology): “There is currently conflicting evidence on the extent to which gene conversion is important in affecting patterns of polymorphism in humans (e.g. Przeworski and Wall (2001), Frisse et al. (2001) and Jeffreys et al. (2001)).”
A haplotype map of the human genome (2003, background): “The approach identifies recombinational hot spots described in the original studies (5, 10, 35) and has been applied successfully to other datasets (18).”
Haplotype blocks and linkage disequilibrium in the human genome (2003, background): “It has been argued that variation in recombination rates is an essential determinant of LD in human”
Genome-wide association studies: theoretical and practical concerns (2005, background): “Regions of low LD might well be regions of intense homologous recombination and GENE CONVERSION , causing the scrambling of the association of alleles between loci — and so the reduction in LD — at a faster rate than regions with less recombinatio”