Haplotype blocks and linkage disequilibrium in the human genome

By Jeffrey D. Wall, J. K. Pritchard. Nature reviews genetics, 2003

691 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f751a2386ef3bc9e1980d194ec76a1ea8b604bbb

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Citations in the corpus

The power and promise of population genomics: from genotyping to genome typing (2003, background): “Complementary population-genomic approaches, such as quantitative trait loci (QTL) mapping in controlled populations, population-based mapping of genes through linkage disequilibrium (LD) and association studies, have been reviewed elsewher”
Linkage disequilibrium — understanding the evolutionary past and mapping the medical future (2008, background): “Haplotype blocks in humans vary in size from a few kb to more than 100 k”
Applications of Linkage Disequilibrium and Association Mapping in Crop Plants (2007, positive): “The hardship is mostly due to the large number of interrelated factors involved in the formation of patterns of LD, including but not limited to genetic drift, population admixture, and natural selection (Pritchard and Przeworski 2001; Wall and Pritchard 2003).”
Approximately independent linkage disequilibrium blocks in human populations (2015, background): “…a local search in the proximity of each minimum from Step 4 in order to fine-tune the segment boundaries In reality, matrix P turns out to be sparse, approx. banded, and approx. block-diagonal, with sporadically overlapping blocks [Slatkin, 2008; Wall and Pritchard, 2003; Wen and Stephens, 2010].”
Genetics and biology of vitamin D receptor polymorphisms. (2004, background): “Linkage disequilibrium (LD) measures describe the association (or co-occurrence) of alleles of adjacent polymorphisms with each other (Wall and Pritchard, 2003).”
Applications of Linkage Disequilibrium and Association Mapping in Maize (2009, background): “The hardship is mostly due to the large number of interrelated factors involved in the formation of patterns of LD, including but not limited to genetic drift, population admixture, and natural selection (Pritchard and Przeworski 2001; Wall and Pritchard 2003).”
The Pattern of Polymorphism in Arabidopsis thaliana (2005, neutral): “in humans [7–9].”
Genome-wide association studies: theoretical and practical concerns (2005, background): “The continuing HapMap project and several recent additional studies indicate that approximately 70–80% of the genome has regions of high L”