High-resolution haplotype structure in the human genome

By Mark J. Daly, J. Rioux, S. Schaffner, T. Hudson, Eric S. Lander. Nature Genetics, 2001

1,807 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9da5838daaaef4cb55b51cab7495a3cdeea37501

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In Genetics

Citations in the corpus

A review of feature selection techniques in bioinformatics (2007, background): “One approach is based on the hypothesis that the human genome can be viewed as a set of discrete blocks that only share a very small set of common haplotypes [21].”
Genome-wide association studies for common diseases and complex traits (2005, background): “Most of the genome falls into segments of strong LD, within which variants are strongly correlated with each other, and most chromosomes carry one of only a few common HAPLOTYPES”
MaCH: Using Sequence and Genotype Data to Estimate Haplotypes and Unobserved Genotypes (2010, background): “, 1996; Lander and Green, 1987] and shares several features with other HMMs used to describe sampled haplotypes as a mosaic of a set of reference haplotypes [Daly et al., 2001; Li and Stephens, 2003; Mott et al., 2000; Stephens and Scheet, 2005a].”
Novel genetic mapping tools in plants: SNPs and LD-based approaches (2002, background): “Furthermore, large DNA segments with extensive LD and a small number of haplotypes appear to be interspersed with regions of high recombination [25, 26 ]”
Accessing genetic variation: genotyping single nucleotide polymorphisms (2001, background): “But how many SNPs are needed? Although recent studies indicate that LD is structured into discrete blocks in the human genom”
Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. (2002, background): “In view of the recent data showing the punctate, usually 10–100-kb haplotype block structure of the human genome (Daly et al. 2001; Johnson et al. 2001; Reich et al. 2001), confirmation that the dysbindin gene is the sole susceptibility gene in this region may be relatively straightforward, since th”
A haplotype map of the human genome. (2003, background): “Several studies have reported observations to this extent (5, 22).”
Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms. (2002, methodology): “Haplotypes not only are more informative but also capture the regional LD information, which is arguably more robust and powerful (Akey et al. 2001; Daly et al. 2001; Pritchard 2001).”
Applications of Linkage Disequilibrium and Association Mapping in Crop Plants (2007, neutral): “(Ackerman et al. 2003; Daly et al. 2001; Forton et al. 2005; Gabriel et al. 2002; Halldorsson et al. 2004; Johnson et al. 2001; Ke and Cardon 2003; Patil et al. 2001; Sebastiani et al. 2003; Zhang and Jin 2003).”
The future of association studies: gene-based analysis and replication. (2004, background): “The presence of LD between some nearby variants means that full information often can be obtained by genotyping only a subset of the variants and by considering their joint haplotypes (Daly et al. 2001; Johnson et al. 2001; Patil et al. 2001; Gabriel et al. 2002; Ardlie et al. 2002).”
A haplotype map of the human genome (2003, background): “Several studies have reported observations to this extent (5, 22).”