Melt extrusion: from process to drug delivery technology.

By J. Breitenbach. European journal of pharmaceutics and biopharmaceutics, 2002

806 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/887518d854b67704369d0b74f3afbc2d5e0b3629

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In Materials Chemistry

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Citations in the corpus

Nanosuspensions: a promising drug delivery strategy (2004, background): “…emulsions (Floyd 1999; Nakano 2000), microemulsions (Lawrence & Rees 2000), solid dispersion technology (Serajuddin 1999; Leuner &Dressman 2000; Breitenbach 2002) and inclusion complexes employing cyclodextrins (Loftsson & Brewster 1996; Stella & Rajewski 1997; Akers 2002), there is no…”
A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products (2012, methodology): “This process results in a gradual increase in pressure along the length of the compression zone, which effectively imparts a high degree of mixing and compression to the material (by decreasing the screw pitch and/or the flight depth) [9, 15].”
New challenges in polymer foaming: A review of extrusion processes assisted by supercritical carbon dioxide (2011, methodology): “Melt extrusion has been used by the pharmaceutical industry for decades to make solid dispersions of poorly soluble drugs because such dispersions enhance bioavailability [3].”
Strategies to Address Low Drug Solubility in Discovery and Development (2013, methodology): “HME can be used in batch mode or adapted for continuous production (Breitenbach, 2002).”
Effect of geometry on drug release from 3D printed tablets. (2015, methodology): “Several research groups have demonstrated HME processes as a viable method to prepare a wide range of accepted pharmaceutical drug delivery systems, including granules, pellets, transdermal patches, transmucosal films systems and implants (Breitenbach, 2002; Crowley et al., 2007; Fonteyne et al., 20”
Pharmaceutical Applications of Hot-Melt Extrusion: Part I (2007, background): “Corotating twin-screw extruders on the other hand are generally of the intermeshing design, and are thus self-wiping (Breitenbach, 2002).”