Strategies to Address Low Drug Solubility in Discovery and Development

By H. Williams, Natalie L. Trevaskis, S. Charman, R. Shanker, W. Charman, Colin W. Pouton, Christopher J. H. Porter. Pharmacological Reviews, 2013

1,466 citations recorded by the source corpus.

Subfields: Materials Chemistry, Pharmaceutical Science, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/071551a9a767b8c4a784be3b1c6009e0c59fbb2b

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Citations in the corpus

• Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability (2014, methodology): “Williams et al. (2013) and Sun et al. (2012) have separately reported that particle size reduction indeed has effects on the kinetic solubility of the substance and according to Ostwald-Freundlich Equation (Equation (1)), the solubility increases significantly on reducing particle size below 1 m m…”