Nanosuspensions: a promising drug delivery strategy

By V. Patravale, A. Date, Raviraj M. Kulkarni. The Journal of pharmacy and pharmacology, 2004

889 citations recorded by the source corpus.

Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Techniques such as media milling and high‐pressure homogenization have been used commercially for producing nanosuspensions. Recently, the engineering of nanosuspensions employing emulsions and microemulsions as templates has been addressed in the literature. The unique features of nanosuspensions have enabled their use in various dosage forms, including specialized delivery systems such as mucoadhesive hydrogels. Rapid strides have been made in the delivery of nanosuspensions by parenteral, peroral, ocular and pulmonary routes. Currently, efforts are being directed to extending their applications in site‐specific drug delivery.

Subfields: Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/48ff4162b90a42a6ce80cbc1abbe0b49fbc5a599

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In Pharmaceutical Science

Citations in the corpus

Drug Solubility: Importance and Enhancement Techniques (2012, methodology): “Various methods utilized for preparation of nanosuspensions include precipitation technique, media milling, highpressure homogenization in water, high pressure homogenization in nonaqueous media, and combination of Precipitation and high-Pressure homogenization [27, 28].”
Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. (2008, neutral): “…Müller et al., 1999b; Müller et al., 2000a; Müller et al., 2000b; Müller et al., 2001; Merisko-Liversidge et al., 2003; Müller and Keck, 2004; Patravale et al., 2004; Rabinow, 2004; Rao et al., 2004; Gupta, 2006), their manufacturing techniques (Jahnke, 1998; Horn and Rieger, 2001; Müller et…”
Ocular drug delivery systems: An overview (2013, background): “For ocular delivery, it provides several advantages such as sterilization, ease of eye drop formulation, less irritation, increase precorneal residence time and enhancement in ocular bioavailability of drugs which are insoluble in tear fluid[68].”
Strategies to Address Low Drug Solubility in Discovery and Development (2013, background): “A number of piston-gap homogenizers have also been described (Patravale et al., 2004) and include the APV Micron Lab 40 (APV Deutschland GmbH, Lubeck, Germany), the EmulsiFlexC3 and C5 (Avestin Inc.”
PLGA-based nanoparticles: an overview of biomedical applications. (2012, neutral): “They have a suitable size [140–142].”
Targeted Delivery of Pesticides Using Biodegradable Polymeric Nanoparticles (2013, background): “When the particle size of the poorly water-soluble larvicidal agent is reduced to a nanoscale, it results in higher water solubility and dissolution rate (Patravale and Kulkarni 2004).”
Nanosuspension: An approach to enhance solubility of drugs (2011, methodology): “Residues left behind in the finished product is a major problem of this method.[20]”