A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products
By Mohammed Maniruzzaman, J. Boateng, M. Snowden, D. Douroumis. ISRN Pharmaceutics, 2012
314 citations recorded by the source corpus.
Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targeted drug delivery resulting in improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). This paper reviews the innumerable benefits of HME, based on a holistic perspective of the equipment, processing technologies to the materials, novel formulation design and developments, and its varied applications in oral drug delivery systems.
Subfields: Materials Chemistry, Molecular Biology, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/331fe3bab635d15a25d912a99d7256bd23005633
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Citations in the corpus
- Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications (2016, background): “hot melt extrusion process.[47] A blend of actives, thermoplastic polymers and excipients without any solvents is passed”
- Thin films as an emerging platform for drug delivery (2016, background): “of polymer with or without a plasticizer [1].”