Effect of geometry on drug release from 3D printed tablets.
By A. Goyanes, Pamela Robles Martinez, A. Buanz, Abdul Basit, S. Gaisford. International journal of pharmaceutics, 2015
609 citations recorded by the source corpus.
The aim of this work was to explore the feasibility of combining hot melt extrusion (HME) with 3D printing (3DP) technology, with a view to producing different shaped tablets which would be otherwise difficult to produce using traditional methods. A filament extruder was used to obtain approx. 4% paracetamol loaded filaments of polyvinyl alcohol with characteristics suitable for use in fused-deposition modelling 3DP. Five different tablet geometries were successfully 3D-printed-cube, pyramid, cylinder, sphere and torus. The printing process did not affect the stability of the drug. Drug release from the tablets was not dependent on the surface area but instead on surface area to volume ratio, indicating the influence that geometrical shape has on drug release. An erosion-mediated process controlled drug release. This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction.
View Paper: https://www.semanticscholar.org/paper/e0ecee53ed9f45b519cd8383cf6fe81402d09e0c
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Citations in the corpus
- A new chapter in pharmaceutical manufacturing: 3D‐printed drug products☆, ☆☆ (2017, background): “Strategies for increasing dissolution rates include printing high-surface-area shapes [44] and printing amorphous dispersions by hot melt extrusion [7,30].”
- 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems. (2016, methodology): “Indeed, numerous pharmaceutical companies have shown growing interest in the HME process to develop different dosage forms such as tablets (e.g. Kaletra® [Abott]), implants (e.g. Ozurdex® [Allergan]) and medical devices (Nuvaring® [Mercks]) [Goyanes et al., 2015b].”