Creating new fluorescent probes for cell biology

By Jin Zhang, Robert E. Campbell, A. Ting, Roger Tsien. Nature reviews. Molecular cell biology, 2003

671 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/875bff1d65b5bfb28bf73b72187cc6514e457ab3

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In Organic Chemistry

Citations in the corpus

Imaging mass spectrometry. (2007, methodology): “…is well established for tracing the distribution of peptides and proteins in tissue sections and GFPderived labeling techniques are now extensively used to study protein dynamics, spatial and temporal, in living systems (Bastiaens & Pepperkok, 2000; Zhang et al., 2002; Phizicky et al., 2003).”
Fluorescent proteins and their applications in imaging living cells and tissues. (2010, background): “This approach has resulted in a great number of FP-based sensors for monitoring specific physiological events in living cells and tissues by means of fluorescent microscopy, spectroscopy, and flow cytometry analysis (129, 195, 290, 408, 449, 513).”
Genetically encoded fluorescent indicator for intracellular hydrogen peroxide (2006, background): “Green fluorescent protein (GFP) and its variants can be used to develop genetically encoded intracellular indicators for different cellular events and condition”
Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy (2004, methodology): “Such imaging has used two groups of organic fluorophores: the fluorescent proteins expressed by the cells themselves and fluorescent dyes that are exogenously loaded into the cell”
Direct stochastic optical reconstruction microscopy with standard fluorescent probes (2011, background): “Fusion proteins are very successfully used to study localization of proteins, dynamic processes and protein-protein interactions in cell”
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein (2004, neutral): “dtd" [ ]> Fluorescent proteins are genetically encoded, easily imaged reporters crucial in biology and biotechnolog”
Fluorescence molecular imaging. (2006, background): “Cloning of the red fluorescent protein (RFP) (45) and evolution [some using exciting new methodologies such as somatic hypermutation (46, 47)] has yielded a number of important new variants that emit well beyond the 600 nm barrier.”
A guide to choosing fluorescent proteins (2005, methodology): “For more complex imaging experiments, such as those using fluorescence resonance energy transfer (FRET”
Apoptosis: A Review of Programmed Cell Death (2007, background): “Recent research with PARP-1 knockout mice indicates that the use of PARP-1 inhibitors may be an effective therapy for the injury associated with myocardial ischemia and reperfusion injury (Zhou et al., 2006).”
Chemistry in living systems (2005, background): “Peptidotriazoles on solid phase: [1,2,3]triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.”