Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy

By E. Voura, J. Jaiswal, H. Mattoussi, S. Simon. Nature Medicine, 2004

670 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/659fb45c4248ff309fd28e4641a48e8080c737f3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

1. Xiaohu Gao
2. Shuming Nie
3. J. Novak
4. Ron C. Hardman
5. Maureen A. Walling
6. J. R. Shepard

In Molecular Biology

1. Shuming Nie
2. Xiaohu Gao
3. I. Rubinstein
4. O. Koo
5. James P. Quigley
6. J. Novak
7. T. Jacks
8. Ron C. Hardman

Citations in the corpus

• Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine (2019, methodology): “Cells labeled with QDs were intravenously injected into a living animal (mice) and followed during tumor cell extravasation into the lung tissue, by detecting the emission spectrum by scanning multiphoton microscopy [129].”
• Role of nanotechnology in targeted drug delivery and imaging: a concise review. (2005, background): “By using QD-labeled tumor cells, it was possible to follow their paths after intraveneous administration as they extravasated into the lungs [201].”
• Quantum Dots for Live Cell and In Vivo Imaging (2009, background): “The occurrence of FRET was confirmed by observing the labeled cells at the both quantum dot and dye emission wavelengths.”
• Nanomedicine: current status and future prospects (2005, background): “Indeed, a recent report demonstrated the use of QDs for tracking metastatic tumor cell extravasation (20).”
• Matrix metalloproteinases and tumor metastasis (2006, background): “In vivo microscopy allows now for observing extravasation at the single-cell level [148, 165, 179].”
• Treating metastatic cancer with nanotechnology (2011, methodology): “Quantum dots have been used efficaciously to track metastatic cell”
• A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors (2005, background): “Of note, those studies that observed no cytotoxicity generally employed protocols that used short-term acute exposures, where cells were in contact with QDs for 15 min to 8 hr (e.g., Hanaki et al. 2003; Jaiswal et al. 2003; Voura et al. 2004).”
• In vivo molecular and cellular imaging with quantum dots. (2005, methodology): “A surprising finding was that two billion QDs could be delivered into the nucleus of a single cell, without compromising its viability, proliferation or migration [24 ,44 ,47].”