Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

By Phillip L. Lowrey, K. Shimomura, M. Antoch, S. Yamazaki, Peter D. Zemenides, M. Ralph, M. Menaker, J. Takahashi. Science, 2000

877 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/87463ed2a0f14dfa609f1c09e2e4eb71d8b16eb0

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome (2005, background): “The Syrian hamster tau mutation was identified in the gene for casein kinase Ie ( CKIe ), a mammalian homologue of Drosophila dbt”
Molecular components of the Mammalian circadian clock. (2013, background): “This shortened period results from a mutation in the enzyme casein kinase 1ε (CK1ε), a kinase which phosphorylates the PER proteins (Lowrey et al. 2000).”
Time zones: a comparative genetics of circadian clocks (2001, background): “The mutant hamsters produce casein kinase 1e with a single amino-acid substitution that is defective for PER phosphorylation in vitro”
Post-translational modifications regulate the ticking of the circadian clock (2007, neutral): “This short period arises from a point mutation in the kinase domain of CKIe, a mutation that decreases the activity of the kinase eightfold in vitro”
Physiology of circadian entrainment. (2010, background): “The ck1 tau mutation represented the first complete description of a circadian mutant in mammals (285, 286, 409), and in addition, it fosters changes in entrainment, including a larger response to light pulses (439, 440).”
Molecular components of the mammalian circadian clock. (2006, background): “This shortened period results from a mutation in the enzyme casein kinase 1ε (CK1ε), a kinase which phosphorylates the PER proteins (Lowrey et al. 2000).”
Coordination of circadian timing in mammals (2002, background): “So which kinases are important for the mammalian clockwork? Casein kinase Ie (CKIe) is an important clock modulator in Syrian hamsters, because a defect in the hamster CK1e gene corresponds to the short-period tau mutatio”
Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. (2001, background): “…assays using cell culture systems indicate that mPER1 can modestly inhibit transcription in- (Camacho et al., 2001; Keesler et al., 2000; Kume et al., 1999; Lowrey et al., 2000; Vielhaber et al., 2000; Yagitaduced by CLOCK:BMAL1:E-box complexes (Jin et al., 1999; Sangoram et al., 1998).”
The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “The hamster tau mutant has a short 20-hour circadian period, which is caused by an A178C missense mutation in Csnk1e leading to a dominant negative mutant allel”
microRNA modulation of circadian-clock period and entrainment. (2007, neutral): “In addition to transcription, post-translational regulation plays a critical role in clock timing processes (Lowrey et al., 2000).”
A clockwork web: circadian timing in brain and periphery, in health and disease (2003, background): “For example, hypophosphorylation of Per2, either because of a mutation of the casein kinase (CK1e) enzyme in the tau mutant hamste”