Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.

By K. Bae, Xiaowei Jin, E. Maywood, Michael H. Hastings, Steven M. Reppert, D. Weaver. Neuron, 2001

898 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/a6fc6cb5107721f1ea4c6d114f45d384e2cf286b

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In Endocrine and Autonomic Systems

In Plant Science

Citations in the corpus

System-level identification of transcriptional circuits underlying mammalian circadian clocks (2005, background): “( Clock and Arntl , also called Bmal1 or Mop3 ), two period gene”
Molecular Architecture of the Mammalian Circadian Clock (2013, background): “For example, both Period genes (Per 1 and Per2) are required for cycling [18], perhaps due to their low abundance as the stoichiometrically limiting factor in forming key clock protein complexes [19].”
Mammalian circadian biology: elucidating genome-wide levels of temporal organization. (2004, background): “Because the absence of PER3 protein had no effect on circadian behavior either in Per1ldc/Per3 or Per2ldc/Per3 double mutant mice, Per3 is not an essential component of the circadian core oscillatory mechanism; however, it may play a role in clock output pathways (13, 181).”
Coordination of circadian timing in mammals (2002, background): “mPER and mCRY outputs of the negative feedback loop are essential for maintaining a functioning circadian clock, as disruption of either the mPer1 and mPer2 genes together or both mCry genes causes immediate behavioural arrhythmicity when the double-knockout animals ”
Circadian Rhythms in Isolated Brain Regions (2002, background): “The Per1 gene plays a role in the molecular mechanism underlying circadian rhythmicity in mammals (Bae et al., 2001; Zheng et al., 2001).”
Intercellular coupling confers robustness against mutations in the SCN circadian clock network. (2007, methodology): “Behavioral phenotypes of these mice were similar to the respective knockout animals not carrying the reporter (Table S1; van der Horst et al., 1999; Shearman et al., 2000; Bae et al., 2001).”
Molecular components of the mammalian circadian clock. (2006, background): “5-h period reduction (Zheng et al. 2001; Cermakian et al. 2001; Bae et al. 2001; Zheng et al. 1999).”
Molecular components of the Mammalian circadian clock. (2013, background): “Importantly, at both the behavioral and molecular level, at least one member of each family is critical for circadian rhythmicity, as Per1 / ;Per2 / mice andCry1 / ;Cry2 / mice display no signs of intrinsic circadian rhythmicity (Bae et al. 2001; Zheng et al. 1999; Thresher et al. 1998; Vitaterna et”