Activation of Lysosomal Function During Dendritic Cell Maturation
By E. Trombetta, Melanie Ebersold, W. Garrett, M. Pypaert, I. Mellman. Science, 2003
754 citations recorded by the source corpus.
Subfields: Epidemiology, Immunology
View Paper: https://www.semanticscholar.org/paper/86f57c2c3565692cf12d36bae3f7100f7190d7d9
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Citations in the corpus
- TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling (2020, background): “LPS upregulates the cell surface level of MHC II at various steps of the formation of antigen-MHC II complexes, including enhanced lysosomal acidification, proteolysis yielding antigens, and transport of the complexes to the surface of DC [121, 122].”
- Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology (2007, background): “Increased assembly of V-ATPase complexes also occurs in dendritic cells upon activation of antigen processin”
- T-cell-antigen recognition and the immunological synapse (2003, background): “, DCs upregulate their ability to process extracellular antigen and to provide co-stimulatio”
- Endosome maturation (2011, background): “The regulation of lumenal pH involves adjustment of the V-ATPase concentration in the membrane, selection of V-ATPase isoforms, as well as the association and dissociation of the V0 and V1 complexes (Trombetta et al, 2003; Kane, 2006; Lafourcade et al, 2008).”
- NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. (2006, background): “, 2002) and that lysosome acidification in immature DCs is inefficient due to limited recruitment of the cytosolic subunits of the V-ATPase to endosomes and lysosomes, as compared to macrophages or mature DCs (Trombetta et al., 2003).”
- Towards a systems understanding of MHC class I and MHC class II antigen presentation (2011, background): “Finally, degradation of antigens is delayed in immature DCs, possibly as a mechanism to store antigens for presentation over long periods of tim”