Towards a systems understanding of MHC class I and MHC class II antigen presentation

By J. Neefjes, M. Jongsma, Petra Paul, O. Bakke. Nature reviews. Immunology, 2011

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Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures (2016, background): “A CD8 T cell can proliferate when its T cell receptor (TCR) recognizes antigens presented by MHC-I on a target cell, leading to an antigen-specific immune response that kills antigen-bearing cells [12].”
Present Yourself! By MHC Class I and MHC Class II Molecules (2016, background): “How MHC I manages to present a blueprint of the intracellular proteome has been established over the last 25 years[20] (Figure 2).”
A guide to antigen processing and presentation (2022, neutral): “Figure adapted from reF.(10), Springer Nature Limited.”
Molecular definitions of autophagy and related processes (2017, neutral): “Proteasomal degradation results in short peptides (of 8 – 12 residues) that are not necessarily degraded further, but may feed into additional processes including (but not limited to) antigen presentation at the plasma membrane (Neefjes et al , 2011).”
A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations (2018, background): “Through this process, a large and heterogeneous pool of p/MHC antigens is continuously generated in healthy, pathogen infected, or tumor cells as a means of displaying a cell’s peptide repertoire to the immune system (4).”