Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

By M. Forgac. Nature reviews. Molecular cell biology, 2007

1,555 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/decbb92b8d54c63537ae166b0e8992fb33fe816a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Endosome maturation (2011, background): “The regulation of lumenal pH involves adjustment of the V-ATPase concentration in the membrane, selection of V-ATPase isoforms, as well as the association and dissociation of the V0 and V1 complexes (Trombetta et al, 2003; Kane, 2006; Lafourcade et al, 2008).”
Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “Although additional regulation of the V-ATPase through subunit assembly, regulation of pump activity, or pump abundance might all contribute to the establishment of compartment-specific pH (Forgac, 2007; Marshansky and Futai, 2008), evidence in yeast, plants, and animals supports the role of H+-coup”
An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1 (2012, neutral): “and V1 domains, two multisubunit complexes (Forgac, 2007), both of which interact with Ragulator (Zoncu et al.”
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations (2010, neutral): “The v-ATPases are multisubunit complexes which are composed of a membrane-bound subcomplex V0 and a cytosolic V1 subcomplex (Forgac, 2007).”
Models for the a subunits of the Thermus thermophilus V/A-ATPase and Saccharomyces cerevisiae V-ATPase enzymes by cryo-EM and evolutionary covariance (2016, background): “These complexes are essential for processes including receptor-mediated endocytosis, coupled transport, and lysosomal degradation (1).”
Lysosomes as a therapeutic target (2019, background): “This acidic environment is maintained through the activity of a vacuolar type proton adeno sine triphosphatase (v ATPase), which harnesses energy from hydrolysing ATP to drive the translocation of protons through a V 0 membrane domain (reviewed elsewhere 5, 21 ).”
Sensors and regulators of intracellular pH (2010, background): “These cells express on their surface vacuolar-type (V) electrogenic H + -ATP hydrolases (V-ATPases) — energy-driven active proton pumps that are similar to those found in endomembranes (see below) and are characteristically sensitive to macrolide antibiotics such as bafilomyci”
Bacillus: A Biological Tool for Crop Improvement through Bio-Molecular Changes in Adverse Environments (2017, background): “Vacuolar H-ATPase regulates the pH of cells, which results to stabilize the membrane, protein degradation, transport of small molecules and several metabolisms (Forgac, 2007).”