Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
By B. Mao, Wei Wu, G. Davidson, J. Marhold, Mingfa Li, B. Mechler, H. Delius, Dana Hoppe, P. Stannek, Carmen Walter and 2 more. Nature, 2002
619 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/86814f387e84a2557d6d80a1e01393b2849787b0
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Citations in the corpus
- Wnt/beta-catenin signaling in development and disease. (2006, unknown): “For recent comprehensive overviews on the other Wnt signaling pathways, the reader is referred to Katoh (2005) and Kohn and Moon (2005).”
- Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface (2003, background): “The two other cysteines in Hh are not disulphide linked and have free sulfhydryl (SH) groups.”
- Dorsal-ventral patterning and neural induction in Xenopus embryos. (2004, background): “The resulting trimolecular complex of LRP5/6, Dkk, and Kremen is endocytosed, resulting in the depletion of LRP5/6 coreceptor from the plasma membrane (Mao et al. 2002).”
- Sex differences in human adipose tissues – the biology of pear shape (2012, background): “Both KREMEN1 and RSPO3 interact with the Wnt signaling pathway, which in turn plays a fundamental role in adipocyte differentiation [62,63].”
- The Wnt signaling pathway in development and disease. (2004, background): “It binds to LRP with high affinity (Bafico et al. 2001, Mao et al. 2001a, Semenov et al. 2001) and to another class of transmembrane molecules, the Kremens (Mao & Niehrs 2003, Mao et al. 2002).”
- Towards an integrated view of Wnt signaling in development (2009, background): “By helping to promote this Dkk-mediated internalization of LRP, Kremen negatively regulates Wnt/β-catenin signaling (Mao et al., 2002).”
- Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities (2022, background): “However, DKKs are downstream targets of Wnt/β-catenin signalling, suggesting a negative feedback mechanism to govern WNT signalling.(32,33) ROR and RYK are located on the plasma membrane, and both act as coreceptors of Wnt ligands in the Wnt/β-catenin signalling pathway.”
- Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer (2021, background): “of this notion, DKK proteins were reported to negatively affect the surface expression of Kremen, and DKK3 was shown to inhibit Wnt signaling by triggering LRP5/6 internalization through the formation of a ternary complex with Kremen1/2 receptors.(191,192,277) In contrast, Ferrari et al.”