Regulation of glutathione synthesis.

By Shelly C. Lu. Molecular Aspects of Medicine, 2009

2,146 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/86806c025b911ce95a645ae5d06f82783cbb8e16

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Citations in the corpus

Glutathione metabolism in cancer progression and treatment resistance (2018, background): “This dipeptide is then combined with glycine by GSH synthetase (GSS) to produce GSH (Lu, 2009).”
Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions (2012, background): “The paper provides starting points for development of novel tools and provides a hypothesis for investigation of the physiology and biochemistry of glutathione with a focus on human and animal health.”
GLUTATHIONE SYNTHESIS (2012, background): “Thus, severe oxidative stress depletes cellular GSH [13] (Figure 2).”
Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “Experiments have shown that the DNA binding capacity of some transcription factors depends on the redox state of thiol groups on cysteine residues as the target of regulation (Lu 2009).”
Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria (2010, neutral): “Because the availability of intracellular cysteine [cysteine (in)] limits the production of GSH (35), we examined whether the increases of extracellular cysteine [cysteine (ex)] contributed to the synthesis of GSH by using cultures of rat primary cortical neurons.”
The chemistry and biological activities of N-acetylcysteine. (2013, background): “The synthesis of GSH is tightly regulated at various levels and is kept at the mM concentration range [21].”
Glutathione in plants: an integrated overview. (2012, positive): “Glutathione is one of the major forms of organic sulphur translocated in the phloem (Herschbach & Rennenberg 1994, 1995; Bourgis et al. 1999; Mendoza-Cózatl et al. 2008), and must therefore move between cells, either apoplastically, symplastically or both.”
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “117,118 The availability of cellular GSH closely regulates the cellular GPX4 activity.”
The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, neutral): “In most tissues, the rate-limiting amino acid for GSH synthesis is the nonessential amino acid cysteine (160, 179).”
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. (2012, background): “Nrf2 activates both genes encoding the catalytic and regulatory subunits of gamma-glutamyl-cysteinyl-ligase (GCL), a ratelimiting enzyme of glutathione synthesis (Lu, 2009).”
Role of Glutathione in Cancer Progression and Chemoresistance (2013, background): “Intracellularly, the majority of GSH is found in the cytosol (about 90%), whilemitochondria contain nearly 10% and the endoplasmic reticulum contains a very small percentage [17].”