Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?

By P. Hassa, Sandra S Haenni, M. Elser, M. Hottiger. Microbiology and Molecular Biology Reviews, 2006

700 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/865c0579e78d2233ec1f1409cf0d6124541bcf42

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Johan Auwerx
2. C. Cantó
3. E. Verdin
4. R. Houtkooper
5. L. Saunders
6. R. Wanders
7. D. Sinclair
8. Bor Luen Tang

In Oncology

1. Johan Auwerx
2. C. Cantó
3. E. Verdin
4. R. Houtkooper
5. M. Hottiger
6. P. Hassa
7. W. Kraus

In Physiology

1. Johan Auwerx
2. C. Cantó
3. E. Verdin
4. R. Houtkooper
5. L. Saunders
6. M. Hottiger
7. R. Wanders
8. P. Hassa

Citations in the corpus

• The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. (2008, background): “ribose-glycohydrolase or poly-ADP-ribosyl-proteinhydrolase activity and immediately release the poly-ADPribose-ribose polymers remains to be investigated (4).”
• Regulation of nucleosome dynamics by histone modifications (2013, unknown): “All four core histones, as well as linker histone H1, are known to be mono–ADP-ribosylated and poly–ADP-ribosylated in a variety of biological contexts 63 .”
• The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets (2010, unknown): “…and PARP-like genes have been identified in a wide variety of single and multicellular eukaryotes, from fungi to mammals (but surprisingly not the yeasts S. cerevisae and S. pombe), as well as eubacteria, archaebacteria, and double-stranded DNA viruses (Hassa et al., 2006; Otto et al., 2005).”
• The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “ADP-ribose moiety is not transferred to an acetyl group, as happens with most sirtuins, but instead, it is linked to an amino-acid acceptor (129) (Fig.”
• Epigenetic regulation in psychiatric disorders (2007, background): “The roles of histone ubiquitylation, SUMOylation and ADP ribosylation are less well understoo”
• Sirtuins: critical regulators at the crossroads between cancer and aging (2007, background): “Mono-ADP-ribosylated cellular proteins include histones, high mobility group (HMG) family members, actin, a- and b-tubulin and glutamate dehydrogenase (GDH; Hassa et al., 2006).”