The cellular mechanism of Aire control of T cell tolerance.

By Mark S. Anderson, Emily S. Venanzi, Zhibin Chen, S. Berzins, C. Benoist, D. Mathis. Immunity, 2005

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Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease (2006, background): “in the medullary epithelial cells, whereas the number and in vitro assessed suppressive activity of natural Tregs are reportedly intact (116, 117).”
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells (2007, background): “Evidence suggests that tissue-specific antigens expressed in mTECs contribute to central tolerance in an essential way by inducing recessive tolerance (such as clonal deletion of autoreactive thymocytes”
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR (2008, positive): “Such antigens are expressed in a mosaic fashion (43) and may therefore induce transient rather than sustained TCR signals, which in turn could contribute to the outcome of Foxp3 induction versus negative selection.”
Journey through the thymus: stromal guides for T-cell development and selection (2006, background): “This process of medullary tolerance is shown to occur, at least in part, through the deletion of self-reactive T cell”