The antiquity of RNA-based evolution

By G. F. Joyce. Nature, 2002

952 citations recorded by the source corpus.

Subfields: Astronomy and Astrophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/858b34d67f27f3bcfbcb02ffe745ecc26194f0cd

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Citations in the corpus

Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression (2002, background): “that TPP, coenzyme B 12 and FMN emerged as biological cofactors during the ‘RNA world&rsquo”
More than the sum of their parts: On the evolution of proteins from peptides (2003, positive): “(70) For this reason, peptides may have provided useful cofactorsin anRNAworld, as theyare good chelators of small molecules, can assist redox reactions via their side chains, and have a natural affinity for nucleic acids.”
On the origin of biochemistry at an alkaline hydrothermal vent (2007, methodology): “The RNA world (Gilbert 1986; Joyce 2002) is an essential element of any modern theory about early evolution, because it provides a conceptual framework for thinking about Darwinian selection among self- rans.”
Hydrothermal vents and the origin of life (2008, background): “The view that life arose at a hydrothermal vent is compatible with concepts germane to the RNA worl”
How life began on Earth: a status report (2004, background): “RNA has been found to be an all-in-one molecule that cannot only store information but also catalyze reactions [2].”
Control of gene expression by a natural metabolite-responsive ribozyme (2004, background): “However, it is likely that life passed through a period in evolution wherein RNA had to serve a much larger role as both catalyst and receptor for the production and sensing of metabolic product”
Gene regulation by riboswitches (2004, background): “First, how might early life forms have controlled molecular functions before the emergence of proteins? It is plausible that life passed through an ' RNA WORLD ', in which genetic storage and primitive biological processes were thought to be carried out entirely by RN”
Regulation of bacterial gene expression by riboswitches. (2005, background): “In addition, the characteristics of modern riboswitches hint at the structural sophistication that RNAs may have exhibited several billion years ago during the hypothetical “RNA world” ( 39 ).”
Prebiotic selection and assembly of proteinogenic amino acids and natural nucleotides from complex mixtures (2017, methodology): “Accordingly, it has been recognised that “the chief obstacle to understanding the origin of RNA-based life is identifying a plausible mechanism for overcoming the clutter wrought by prebiotic chemistry”.(4-7) For example, the most-efficient and specific proposed prebiotic pathway to the pyrimidine r”