Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.

By Jörg Urban, A. Soulard, A. Huber, Soyeon I Lippman, D. Mukhopadhyay, O. Deloche, Valeria Wanke, D. Anrather, G. Ammerer, Howard Riezman and 4 more. Molecules and Cells, 2007

824 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/855bf7d0370caf3312ed821c04d5c8c4c190ce5e

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In Ecology, Evolution, Behavior and Systematics

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Citations in the corpus

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control (2011, background): “Sch9 inhibition, however, also leads to eIF2a phosphorylation via an undefined pathway (Urban et al. 2007).”
The regulation of autophagy – unanswered questions (2011, background): “cerevisiae, Sch9 was originally proposed to be an Akt homolog (Sobko, 2006), but a later study demonstrated that Sch9 is more likely to be a S6K1 homolog (Urban et al., 2007), which means it would function as a substrate of TORC1 rather than as its regulator.”
Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae (2014, background): “Increasing evidence points toward the lysosome/vacuole limiting membrane as the main localization for the activation of TORC1 signaling (Kunz et al., 2000; Urban et al., 2007; Sturgill et al., 2008; Binda et al., 2009).”
Glc-TOR signalling leads transcriptome reprogramming and meristem activation (2013, background): “Regulation of transcription (95) Miscellaneous (85) Protein folding (78) Cell wall synthesis (60) Metabolism (56) Signalling (47) RNA synthesis & processing (38) Transporter (37) Amino acid synthesis (31) Protein modification (30) Protein degradation (30) Nucleotide synthesis (29) TCA cycle & ETC (2”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “Treatment with cycloheximide causes a potent increase in TORC1 activity, which can decrease autophagy in part as a result of the increase in the amino acid pool resulting from suppressed protein synthesis (Shen H-M, personal communication).(606,607) In addition, at high concentrations (in the millim”
Nutritional Control of Growth and Development in Yeast (2012, background): “in Yeast”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “Topisirovic, personal communication).(926,927) In addition, at high concentrations (in the millimolar range) cycloheximide inhibits complex I of the mitochondrial respiratory chain,(928,929) but this is not a problem, at least in hepatocytes, at low concentrations (10–20 mM) that are sufficient to p”
With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging (2010, neutral): “TORC1 is rendered less active by high temperature, hydrogen peroxide, and high salt stress in S. cerevisiae (Urban et al., 2007).”
An Overview of the Molecular Mechanism of Autophagy (2009, background): “Sch9 is a homolog of mammalian PKB or p70S6 kinase (Urban et al. 2007).”