Lack of the bone morphogenetic protein BMP6 induces massive iron overload

By Delphine Meynard, Léon Kautz, Valérie Darnaud, F. Canonne-Hergaux, H. Coppin, M. Roth. Nature Genetics, 2009

612 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/70ac23a99f4dcd9ecc6f1aa370a5b3fe804c5d23

How researchers see this paper

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In Genetics

1. T. Ganz
2. R. Derynck
3. E. Nemeth

In Hematology

1. T. Ganz
2. E. Nemeth

In Nutrition and Dietetics

1. T. Ganz

Citations in the corpus

• TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology. (2016, background): “Additionally, BMP-6 was identified as an endogenous ligand that regulates hepcidin expression and iron metabolism in vivo (Andriopoulos et al. 2009; Meynard et al. 2009).”
• Systemic iron homeostasis. (2013, background): “BMP6 is the essential and specific BMP receptor ligand for iron-related signaling, at least in mice, as BMP6 knockout mice have very low hepcidin and develop severe iron overload, with no evidence of any other abnormalities (6, 153).”