Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

By F. Bäckhed, J. Manchester, C. Semenkovich, Jeffrey I. Gordon. Proceedings of the National Academy of Sciences of the United States of America, 2007

2,591 citations recorded by the source corpus.

Subfields: Physiology

View Paper: https://www.semanticscholar.org/paper/84ef3749d767fb7cafd323168e8e2222c6d96036

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In Physiology

Citations in the corpus

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice (2011, background): “Nevertheless, germfree animals have led to striking and unequivocal findings regarding the role of gut microbiota in host energy metabolism (3,17,18).”
Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. (2010, background): “Although previous data demonstrate that total fecal calories, measured by a bomb calorimeter, are similar in GF and conv mice (2), we observed that total fecal lipids were higher in GF/HF than in conv/HF mice.”
Energy intake is associated with endotoxemia in apparently healthy men. (2008, background): “This finding is in contrast with results obtained in mice infused with LPS for 4 wk (4).”
High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse (2010, background): “Consistent with prior findings [12,13], GF mice did not develop insulin resistance as indicated by the lack of significant difference in HOMA at 16 weeks in GF fed HF = 8.”
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments (2010, background): “Recent work has confirmed an association between microbial composition and obesity (2, 4) mediated through several mechanisms such as increased fat storage through fastinginduced adipocyte factor (fiaf) suppression (41), increased energy harvest from the diet, and reduced fatty acid oxidation (42).”
Role of microorganisms in the evolution of animals and plants: the hologenome theory of evolution. (2008, background): “The cross-talk between microbiota and its mouse host regarding energy metabolism involves at least two demonstrated mouse factors (Bäckhed et al., 2007).”
Minireview: Gut microbiota: the neglected endocrine organ. (2014, background): “Bäckhed and co-workers (40) also demonstrated that GF mice fed a high-fat, high-carbohydrate Western diet for 8 weeks gained significantly less weight than mice raised conventionally and were protected against dietinduced glucose intolerance and insulin resistance.”
Dietary lipids, gut microbiota and lipid metabolism (2019, background): “Importantly, GF mice are protected against diet-induced obesity through a combination of several mechanisms including increased fatty acid oxidation and decreased deposition of triglycerides in adipocytes compared to CONV-R mice [29].”
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 (2008, methodology): “Locomotor activity and body temperature were assessed for 5 d using a telemetry device (minimitter PDT-4000; Mini Mitter) beginning 7 d after implantation (20).”