Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

By J. Swann, E. Want, F. Geier, K. Spagou, Ian A. Wilson, J. Sidaway, Jeremy K. Nicholson, Edward C. Holmes. Proceedings of the National Academy of Sciences of the United States of America, 2010

710 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/83febacb99ddced65f6aad180ce8d274b922288a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Oncology

In Pediatrics, Perinatology and Child Health

J. Y. Chiang

Citations in the corpus

Modulation of the Fecal Bile Acid Profile by Gut Microbiota in Cirrhosis (2013, positive): “Apart from their digestive role, bile acids can influence the intestinal milieu, the integrity of the mucosal barrier, and the synthesis of anti-bacterial peptides and lectins [6,7].”
Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota (2016, background): “The gut microbiome produces potent ligands corresponding to BA receptors; probiotics or prebiotics could act as therapeutics of BA dysmetabolism, indicating that microbiota-targeted therapies could be effective in preventing and/or treating gut-related diseases, including AS (40).”
Cultured gut microbiota from twins discordant for obesity modulate adiposity and metabolic phenotypes in mice (2013, positive): “The gut microbiota affects the composition and relative abundance of bile acids species through a variety of metabolic transformations (40, 41).”
Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish (2012, background): “First, microbes might increase bioavailability of FAs by modifying the production or composition of bile salts (Swann et al., 2011).”
Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “More recent studies show that in germ-free mice and antibiotic-treated mice, tauro-conjugated bile acids are predominant in liver, kidney, plasma, and heart, especially tauro-b-muricholic acid (T-b-MCA) (Swann et al., 2011).”
Consequences of bile salt biotransformations by intestinal bacteria (2016, background): “Recent studies also illustrate the important role gut microbes play in the levels and profiles of bile acids in various tissues of the body including liver, kidney, plasma, and heart.(87) The global physiological significance of these alterations in bile acid profiles is unknown.”
Host genetic variation impacts microbiome composition across human body sites (2015, background): “Recent studies have shown that the microbiome can modulate bile acid metabolism [45], and our results support a possible role for host genetic variation in bile acid metabolic pathways in interacting with the microbiota.”